Advertisement

Topics

INFLUENCE OF MICROCRYSTALLINE CELLULOSE MODIFICATION ON THE PHYSICAL PARAMETERS' STABILITY OF DIRECTLY COMPRESSED PLACEBO TABLETS.

07:00 EST 1st January 2017 | BioPortfolio

Summary of "INFLUENCE OF MICROCRYSTALLINE CELLULOSE MODIFICATION ON THE PHYSICAL PARAMETERS' STABILITY OF DIRECTLY COMPRESSED PLACEBO TABLETS."

Directly compressed tablets manufactured with high concentrations of microcrystalline cellulose tend to soften when exposed to high humidity. Modification/co-processing of microcrystalline cellulose with hydrophobic agents using two methods was proposed to prevent hardness decrease of placebo tablets upon moisture absorption. Hardness of placebo tablets before and after exposure to humidity of 75% RH was compared. Hardness of all tested placebo tablets decreased after exposure to humidity of 75% RH, however the extent of decrease was different. Relative hardness decrease was the lowest for modification with use of hydrogenated castor oil. Co-processing of microcrystalline cellulose by 20% addition of hydrogenated castor oil allows to reduce a hardness decrease upon moisture uptake.

Affiliation

Journal Details

This article was published in the following journal.

Name: Acta poloniae pharmaceutica
ISSN: 0001-6837
Pages: 267-275

Links

DeepDyve research library

PubMed Articles [24261 Associated PubMed Articles listed on BioPortfolio]

Entangled and colloidally stable microcrystalline cellulose matrices in controlled drug release.

Drug release from a new type of matrix material consisting of partially fibrillated microcrystalline cellulose was investigated. A mechanical treatment of novel AaltoCell™ cellulose microcrystals ca...

Effect of anti-solvents on the characteristics of regenerated cellulose from 1-ethyl-3-methylimidazolium acetate ionic liquid.

This work investigates the effect of different anti-solvents (water, ethanol, or both water and ethanol) on the characteristics of cellulose dissolved and then generated from 1-ethyl-3-methylimidazoli...

Preparation and characterization of biocomposite packaging film from poly(lactic acid) and acylated microcrystalline cellulose using rice bran oil.

Surface acylation of microcrystalline cellulose (MCC) was performed using rice bran oil (RBO). The resultant acylated MCC (RAMCC) exhibited reduced polarity as compared with MCC. Attenuated Total Refl...

Parsing in vivo and in vitro contributions to microcrystalline cellulose hydrolysis by multi-domain glycoside hydrolases in the Caldicellulosiruptor bescii secretome.

Six multi-domain glycoside hydrolases (GHs), CelA (Athe_1867), CelB (Athe_1859), CelC (Athe_1857), CelD (Athe_1866), CelE (Athe_1865), and CelF (Athe_1860) are encoded in the Caldicellulosiruptor besc...

Effect of lignin as natural polymer on the release rate of acetylsalicylic acid tablets.

The main focus here is on the improvement of formulations utilising non-conventional bio-based excipients to improve tablet release rates. Two different formulations were considered. The first formula...

Clinical Trials [9603 Associated Clinical Trials listed on BioPortfolio]

Comparison of Psyllium and Microcrystalline Cellulose on Glycemic Measures in Subjects With Impaired Fasting Glucose

The Purpose of this study is to compare the effects of 2 types of dietary fiber, psyllium and microcrystalline cellulose (MCC), on glycemic measures in subjects with impaired fasting gluco...

Dextromethorphan as a Novel Non-opioid Adjunctive Agent for Pain Control in Medication Abortion

This study evaluates dextromethorphan as a non-opioid adjunctive medication for pain control during medication abortion. This is double-blinded, four-arm randomized controlled trial enroll...

A Controlled Trial of Plantain Powder in Infantile Diarrhea

Green banana has been traditionally used in diarrheal and other diseases. Recent studies have shown that green banana is beneficial in children with diarrhea. The purpose of this study is...

Curcumin and Function in Older Adults

This placebo-controlled RCT tests whether dietary supplementation with curcumin maintains or improves cognitive and physical function in older adults who are at high risk of functional dec...

CMC I Stability Intraoperative

The goal of the current study is to objectively measure intraoperative the initial thumb stability after trapezium removal when performing trapeziectomy, alone or in combination with suspe...

Medical and Biotech [MESH] Definitions

Diet modification and physical exercise to improve the ability to carry out daily tasks and perform physical activities.

A type of ion exchange chromatography using diethylaminoethyl cellulose (DEAE-CELLULOSE) as a positively charged resin. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)

A branch of physical chemistry which studies chemical reactions, isomerization and physical behavior that may occur under the influence of visible and/or ultraviolet light.

Computers in which quantities are represented by physical variables; problem parameters are translated into equivalent mechanical or electrical circuits as an analog for the physical phenomenon being investigated. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)

The chemical and physical integrity of a pharmaceutical product.

Advertisement
Quick Search
Advertisement
Advertisement

 
DeepDyve research library

Searches Linking to this Article