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Directly compressed tablets manufactured with high concentrations of microcrystalline cellulose tend to soften when exposed to high humidity. Modification/co-processing of microcrystalline cellulose with hydrophobic agents using two methods was proposed to prevent hardness decrease of placebo tablets upon moisture absorption. Hardness of placebo tablets before and after exposure to humidity of 75% RH was compared. Hardness of all tested placebo tablets decreased after exposure to humidity of 75% RH, however the extent of decrease was different. Relative hardness decrease was the lowest for modification with use of hydrogenated castor oil. Co-processing of microcrystalline cellulose by 20% addition of hydrogenated castor oil allows to reduce a hardness decrease upon moisture uptake.
This article was published in the following journal.
Name: Acta poloniae pharmaceutica
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A type of ion exchange chromatography using diethylaminoethyl cellulose (DEAE-CELLULOSE) as a positively charged resin. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
A branch of physical chemistry which studies chemical reactions, isomerization and physical behavior that may occur under the influence of visible and/or ultraviolet light.
Computers in which quantities are represented by physical variables; problem parameters are translated into equivalent mechanical or electrical circuits as an analog for the physical phenomenon being investigated. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
The chemical and physical integrity of a pharmaceutical product.