AltHapAlignR: improved accuracy of RNA-seq analyses through the use of alternative haplotypes.

07:00 EST 5th March 2018 | BioPortfolio

Summary of "AltHapAlignR: improved accuracy of RNA-seq analyses through the use of alternative haplotypes."

Reliance on mapping to a single reference haplotype currently limits accurate estimation of allele or haplotype-specific expression using RNA-sequencing, notably in highly polymorphic regions such as the MHC.


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Name: Bioinformatics (Oxford, England)
ISSN: 1367-4811


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Medical and Biotech [MESH] Definitions

A 20 cM region of mouse chromosome 17 that is represented by a least two HAPLOTYPES. One of the haplotypes is referred to as the t-haplotype and contains an unusual array of mutations that affect embryonic development and male fertility. The t-haplotype is maintained in the gene pool by the presence of unusual features that prevent its recombination.

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A serine protease that cleaves multiple COMPLEMENT C5 into COMPLEMENT C5A (anaphylatoxin) and COMPLEMENT C5B in the ALTERNATIVE COMPLEMENT ACTIVATION PATHWAY. It is the complex of ALTERNATIVE PATHWAY C3 CONVERTASE (C3bBb) with an additional COMPLEMENT C3B, or C3bBb3b.

The closeness of a determined value of a physical dimension to the actual value.

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DNA sequencing
DNA sequencing is the process of determining the precise order of nucleotides within a DNA molecule. During DNA sequencing, the bases of a small fragment of DNA are sequentially identified from signals emitted as each fragment is re-synthesized from a ...

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