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Effects of 5-alpha reductase inhibitors: new insights on benefits and harms.

07:00 EST 9th March 2018 | BioPortfolio

Summary of "Effects of 5-alpha reductase inhibitors: new insights on benefits and harms."

The use of 5-alpha reductase inhibitors (5ARIs) for the treatment of benign prostatic hyperplasia (BPH) and other diseases has been proposed and studied. However, the controversy about its benefits and harms for other diseases has persisted. In this review, we will discuss the newly identified effects of 5ARIs based on recently published studies.

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This article was published in the following journal.

Name: Current opinion in urology
ISSN: 1473-6586
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PubMed Articles [21745 Associated PubMed Articles listed on BioPortfolio]

The use of 5-alpha reductase inhibitors to manage benign prostatic hyperplasia and the risk of all-cause mortality.

To compare the risk of mortality among men treated for benign prostatic hyperplasia (BPH) with 5?-reductase inhibitors (5ARI) to those treated with alpha-blockers (AB) in community practice settings.

Alpha-1 adrenergic antagonists, 5-alpha reductase inhibitors, phosphodiesterase type 5 inhibitors, and phytotherapic compounds in men with lower urinary tract symptoms suggestive of benign prostatic obstruction: A systematic review and meta-analysis of urodynamic studies.

To perform a systematic review and meta-analysis of studies evaluating the urodynamic outcomes of alpha-1 adrenergic antagonists (ABs), 5-alpha reductase inhibitors (5-ARIs), phosphodiesterase type 5 ...

Sexual side effects of 5-α-reductase inhibitors finasteride and dutasteride: A comprehensive review.

The 5-α-reductase inhibitors finasteride and dutasteride are frequently used in the treatment of androgenetic alopecia and benign prostatichyperplasia. These drugs are effective at reducing levels of...

Preoperative treatment with 5α-reductase inhibitors and the risk of hemorrhagic events in patients undergoing transurethral resection of the prostate - A population-based cohort study.

To assess the associations between preoperative treatment with 5-alpha reductase inhibitors and the risks of blood transfusion during transurethral resection of the prostate and blood clot evacuation ...

A Review of the FAERS Data on 5-Alpha Reductase Inhibitors: Implications for Post-Finasteride Syndrome.

To quantify reports made to the Food and Drug Administration Adverse Event Reporting System (FAERS), create a demographic of patient reports, and examine the cluster of symptoms to correlate consisten...

Clinical Trials [5067 Associated Clinical Trials listed on BioPortfolio]

WEUSKOP5723: Prostate Cancer Study

This retrospective cohort study will assess the association of benign prostatic hyperplasia (BPH) treatment (5-alpha reductase inhibitors (5ARI) and alpha-blocker medications) with the occ...

The Effect of 5-Alpha Reductase on Testosterone in Men

The enzyme 5-alpha reductase is present in small amounts in muscle and converts testosterone to dihydrotestosterone (DHT). Testosterone affects lean body tissue, muscle size, muscle stren...

One-Year Prospective Observational Study of BMI Change Effect of 5-Alpha Reductase Inhibitor in Korean BPH Patients

It is widely-accepted that serum testosterone level and BMI (body mass index) representative of the degree of obesity has negative correlation. Considering the fact that obesity is being m...

Effect of Dutasteride on Bladder Wall Hypertrophy in Patients With Benign Prostatic Obstruction

Increased bladder mass occurs as a consequence of bladder outlet obstruction in animals and patients, and relief of bladder outlet obstruction reverses an increased bladder mass. Whether ...

Testing Numeric Formats for Presenting Data About Treatment Benefits and Harms

The purpose of this study is to test comprehension of five numeric formats used to present data about treatment benefits and harms.

Medical and Biotech [MESH] Definitions

Drugs that inhibit 3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE. They are commonly used to reduce the production of DIHYDROTESTOSTERONE.

Aldo-keto reductase that functions with 5-alpha and 5-beta-steroid reductases to convert steroid hormones into the 3-alpha or 5-alpha and 3-alpha or 5-beta-tetrahydrosteroid, including 5-ALPHA-DIHYDROTESTOSTERONE to ANDROSTANE-3,17-DIOL. It also binds to BILE ACIDS. Mutations in the AKR1C2 gene are associated with Type 8 46, XY DISORDERS OF SEX DEVELOPMENT (SRXY8).

A liver microsomal cytochrome P450 enzyme that catalyzes the 12-alpha-hydroxylation of a broad spectrum of sterols in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP8B1gene, converts 7-alpha-hydroxy-4-cholesten-3-one to 7-alpha-12-alpha-dihydroxy-4-cholesten-3-one and is required in the synthesis of BILE ACIDS from cholesterol.

A 1974 Federal act which preempts states' rights with regard to workers' pension benefits and employee benefits. It does not affect the benefits and rights of employees whose employer is self-insured. (From Slee & Slee, Health Care Reform Terms, 1993)

Compounds that inhibit HMG-CoA reductases. They have been shown to directly lower cholesterol synthesis.

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