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APS Sickle Cell Disease Conference Mini-Review: Targeting Pain at its Source in Sickle Cell Disease.

08:00 EDT 28th March 2018 | BioPortfolio

Summary of "APS Sickle Cell Disease Conference Mini-Review: Targeting Pain at its Source in Sickle Cell Disease."

Sickle cell disease (SCD) is a genetic disorder associated with hemolytic anemia, end-organ damage, reduced survival and pain. One of the unique features of SCD is, recurrent and unpredictable episodes of acute pain due to vaso-occlusive crisis, requiring hospitalization. Additionally, SCD patients often develop chronic persistent pain. Currently, sickle pain is treated with opioids, an approach limited by adverse effects. Because pain can start at infancy and continue throughout life, preventing the genesis of pain may be relatively better than treating the pain once it has been evoked. Therefore, we provide insights into the cellular and molecular mechanisms of sickle pain that contribute to the activation of the somatosensory system in the peripheral- and central- nervous systems. These mechanisms include mast cell activation and neurogenic inflammation, peripheral nociceptor sensitization, maladaptation of spinal signals, central sensitization and modulation of neural circuits in the brain. In this review, we describe potential preventive/therapeutic targets and their targeting with novel pharmacologic and/or integrative approaches to ameliorate sickle pain.

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This article was published in the following journal.

Name: American journal of physiology. Regulatory, integrative and comparative physiology
ISSN: 1522-1490
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Medical and Biotech [MESH] Definitions

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