Real-time magnetic actuation of DNA nanodevices via modular integration with stiff micro-levers.

08:00 EDT 13th April 2018 | BioPortfolio

Summary of "Real-time magnetic actuation of DNA nanodevices via modular integration with stiff micro-levers."

DNA nanotechnology has enabled complex nanodevices, but the ability to directly manipulate systems with fast response times remains a key challenge. Current methods of actuation are relatively slow and only direct devices into one or two target configurations. Here we report an approach to control DNA origami assemblies via externally applied magnetic fields using a low-cost platform that enables actuation into many distinct configurations with sub-second response times. The nanodevices in these assemblies are manipulated via mechanically stiff micron-scale lever arms, which rigidly couple movement of a micron size magnetic bead to reconfiguration of the nanodevice while also enabling direct visualization of the conformation. We demonstrate control of three assemblies-a rod, rotor, and hinge-at frequencies up to several Hz and the ability to actuate into many conformations. This level of spatiotemporal control over DNA devices can serve as a foundation for real-time manipulation of molecular and atomic systems.


Journal Details

This article was published in the following journal.

Name: Nature communications
ISSN: 2041-1723
Pages: 1446


DeepDyve research library

PubMed Articles [16803 Associated PubMed Articles listed on BioPortfolio]

Real-time cardiovascular MR with spatio-temporal artifact suppression using deep learning-proof of concept in congenital heart disease.

Real-time assessment of ventricular volumes requires high acceleration factors. Residual convolutional neural networks (CNN) have shown potential for removing artifacts caused by data undersampling. I...

Aberrant Cortical Integration in First-Episode Psychosis During Natural Audiovisual Processing.

Functional magnetic resonance imaging studies of psychotic disorders have reported both hypoactivity and hyperactivity in numerous brain regions. In line with the dysconnection hypothesis, these regio...

Time Propagation and Spectroscopy of Fermionic Systems Using a Stochastic Technique.

We present a stochastic method for solving the time-dependent Schrödinger equation, generalizing a ground state full configuration interaction quantum Monte Carlo method. By performing the time inte...

Rapid detection of multiple respiratory viruses based on microfluidic isothermal amplification and a real-time colorimetric method.

Respiratory viruses are major threats causing development of acute respiratory tract infections, which are common causes of illness and death throughout the world. Here, an integrated microsystem base...

Plasmon Rulers as a Probe for Real-Time Microsecond Conformational Dynamics of Single Molecules.

Biopolymers such as DNA, RNA and proteins exploit conformational changes to modulate their function. Although state-of-the-art single-molecule approaches enable identification of conformational states...

Clinical Trials [6123 Associated Clinical Trials listed on BioPortfolio]

Actuation Indicator Trial in Patients With COPD

The primary objective of this study is to evaluate the performance, accuracy, and handling of the actuation indicator in patients with COPD. The actuation indicator is integrated into mou...

User Evaluation of Advanced Personalized Modular Pressure Relief Seating Cushion Systems

30 Veterans who are full-time wheelchair users will use personalized modular cushions for two weeks each. Personalized cushions will be created using a cushion fitting process the investig...

Effects of Amygdala Neurofeedback on Depressive Symptoms

The purpose of this study is to determine the clinical efficacy of augmenting cognitive-behavioral therapy with real-time functional magnetic resonance imaging neurofeedback (rtfMRI-nf) tr...

Real-Ear Measurement (REM) and Test Box System Integration Into Fitting Software

Integration of the REM-verification within the fitting workflow will enable the hearing care professional to easily run real ear measurements. The purpose of the two study parts is to prov...

Applications of Realtime Functional Magnetic Resonance Imaging (fMRI )

The goal of this research program is to determine the potential effectiveness of real-time fMRI training in improving mental control over pain.

Medical and Biotech [MESH] Definitions

Ultrasonography applying the Doppler effect combined with real-time imaging. The real-time image is created by rapid movement of the ultrasound beam. A powerful advantage of this technique is the ability to estimate the velocity of flow from the Doppler shift frequency.

Insertion of viral DNA into host-cell DNA. This includes integration of phage DNA into bacterial DNA; (LYSOGENY); to form a PROPHAGE or integration of retroviral DNA into cellular DNA to form a PROVIRUS.

Organic chemistry methodology that mimics the modular nature of various biosynthetic processes. It uses highly reliable and selective reactions designed to "click" i.e., rapidly join small modular units together in high yield, without offensive byproducts. In combination with COMBINATORIAL CHEMISTRY TECHNIQUES, it is used for the synthesis of new compounds and combinatorial libraries.

The integration of exogenous DNA into the genome of an organism at sites where its expression can be suitably controlled. This integration occurs as a result of homologous recombination.

Echocardiography applying the Doppler effect, with the superposition of flow information as colors on a gray scale in a real-time image.

Quick Search


DeepDyve research library

Relevant Topics

Bioinformatics is the application of computer software and hardware to the management of biological data to create useful information. Computers are used to gather, store, analyze and integrate biological and genetic information which can then be applied...

Nanotechnology is the engineering of functional systems at the molecular scale. This covers both current work and concepts that are more advanced.  In its original sense, 'nanotechnology' refers to the projected ability to construct items fr...

Searches Linking to this Article