Advertisement

Topics

Real-time magnetic actuation of DNA nanodevices via modular integration with stiff micro-levers.

08:00 EDT 13th April 2018 | BioPortfolio

Summary of "Real-time magnetic actuation of DNA nanodevices via modular integration with stiff micro-levers."

DNA nanotechnology has enabled complex nanodevices, but the ability to directly manipulate systems with fast response times remains a key challenge. Current methods of actuation are relatively slow and only direct devices into one or two target configurations. Here we report an approach to control DNA origami assemblies via externally applied magnetic fields using a low-cost platform that enables actuation into many distinct configurations with sub-second response times. The nanodevices in these assemblies are manipulated via mechanically stiff micron-scale lever arms, which rigidly couple movement of a micron size magnetic bead to reconfiguration of the nanodevice while also enabling direct visualization of the conformation. We demonstrate control of three assemblies-a rod, rotor, and hinge-at frequencies up to several Hz and the ability to actuate into many conformations. This level of spatiotemporal control over DNA devices can serve as a foundation for real-time manipulation of molecular and atomic systems.

Affiliation

Journal Details

This article was published in the following journal.

Name: Nature communications
ISSN: 2041-1723
Pages: 1446

Links

DeepDyve research library

PubMed Articles [16538 Associated PubMed Articles listed on BioPortfolio]

A Novel Magnetic Actuation Scheme to Disaggregate Nanoparticles and Enhance Passage across the Blood-Brain Barrier.

The blood-brain barrier (BBB) hinders drug delivery to the brain. Despite various efforts to develop preprogramed actuation schemes for magnetic drug delivery, the unmodeled aggregation phenomenon lim...

Magnetic resonance imaging guidance for the optimization of ventricular tachycardia ablation.

Catheter ablation has an important role in the management of patients with ventricular tachycardia (VT) but is limited by modest long-term success rates. Magnetic resonance imaging (MRI) can provide v...

Real-time optimization of nuclear magnetic resonance experiments.

Nuclear Magnetic Resonance (NMR) experiments are typically performed with predetermined pulse sequences and acquisition parameters, and are oftentimes sub-optimal for individual samples under investig...

Real-time volumetric relative dosimetry for magnetic resonance - image-guided radiation therapy (MR-IGRT).

The integration of magnetic resonance imaging (MRI) with linear accelerators (linac) has enabled the use of 3D MR-visible gel dosimeters for real-time verification of volumetric dose distributions. Se...

Remote magnetic actuation using a clinical scale system.

Remote magnetic manipulation is a powerful technique for controlling devices inside the human body. It enables actuation and locomotion of tethered and untethered objects without the need for a local ...

Clinical Trials [5495 Associated Clinical Trials listed on BioPortfolio]

Actuation Indicator Trial in Patients With COPD

The primary objective of this study is to evaluate the performance, accuracy, and handling of the actuation indicator in patients with COPD. The actuation indicator is integrated into mou...

User Evaluation of Advanced Personalized Modular Pressure Relief Seating Cushion Systems

30 Veterans who are full-time wheelchair users will use personalized modular cushions for two weeks each. Personalized cushions will be created using a cushion fitting process the investig...

Effects of Amygdala Neurofeedback on Depressive Symptoms

The purpose of this study is to determine the clinical efficacy of augmenting cognitive-behavioral therapy with real-time functional magnetic resonance imaging neurofeedback (rtfMRI-nf) tr...

Real-Ear Measurement (REM) and Test Box System Integration Into Fitting Software

Integration of the REM-verification within the fitting workflow will enable the hearing care professional to easily run real ear measurements. The purpose of the two study parts is to prov...

Applications of Realtime Functional Magnetic Resonance Imaging (fMRI )

The goal of this research program is to determine the potential effectiveness of real-time fMRI training in improving mental control over pain.

Medical and Biotech [MESH] Definitions

Ultrasonography applying the Doppler effect combined with real-time imaging. The real-time image is created by rapid movement of the ultrasound beam. A powerful advantage of this technique is the ability to estimate the velocity of flow from the Doppler shift frequency.

Insertion of viral DNA into host-cell DNA. This includes integration of phage DNA into bacterial DNA; (LYSOGENY); to form a PROPHAGE or integration of retroviral DNA into cellular DNA to form a PROVIRUS.

Organic chemistry methodology that mimics the modular nature of various biosynthetic processes. It uses highly reliable and selective reactions designed to "click" i.e., rapidly join small modular units together in high yield, without offensive byproducts. In combination with COMBINATORIAL CHEMISTRY TECHNIQUES, it is used for the synthesis of new compounds and combinatorial libraries.

The integration of exogenous DNA into the genome of an organism at sites where its expression can be suitably controlled. This integration occurs as a result of homologous recombination.

Echocardiography applying the Doppler effect, with the superposition of flow information as colors on a gray scale in a real-time image.

Advertisement
Quick Search
Advertisement
Advertisement

 


DeepDyve research library

Relevant Topic

Bioinformatics
Bioinformatics is the application of computer software and hardware to the management of biological data to create useful information. Computers are used to gather, store, analyze and integrate biological and genetic information which can then be applied...


Searches Linking to this Article