Characterization of degradation products of Macitentan under various stress conditions by using Liquid Chromatography Mass Spectrometry.

08:00 EDT 16th April 2018 | BioPortfolio

Summary of "Characterization of degradation products of Macitentan under various stress conditions by using Liquid Chromatography Mass Spectrometry."

Stress testing of a drug candidate is an important step in drug discovery and development process. The presence of degradation products in a drug affects the quality as well as safety and efficacy of drug formulation. Hence, it is essential to develop an efficient analytical method which could be useful for the separation, identification and characterization of all possible degradation products of drug. Macitentan (MT) is an endothelin receptor antagonist (ERA) drug used to treat high blood pressure in the lungs. Comprehensive stress testing of MT drug was carried out as per ICH guidelines to understand the degradation profile of the drug.


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This article was published in the following journal.

Name: Rapid communications in mass spectrometry : RCM
ISSN: 1097-0231


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