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Optimization of a drug transporter probe cocktail: potential screening tool for transporter-mediated drug-drug interactions.

08:00 EDT 17th April 2018 | BioPortfolio

Summary of "Optimization of a drug transporter probe cocktail: potential screening tool for transporter-mediated drug-drug interactions."

Previous pharmacokinetic characterization of a transporter probe cocktail containing digoxin (P-gp), furosemide (OAT1, OAT3), metformin (OCT2, MATE1, MATE2-K) and rosuvastatin (OATP1B1, OATP1B3, BCRP) in healthy subjects showed increases in rosuvastatin systemic exposure compared to rosuvastatin alone. In this trial, the doses of metformin and furosemide as putative perpetrators were reduced to eliminate their drug-drug interaction (DDI) with rosuvastatin.

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This article was published in the following journal.

Name: British journal of clinical pharmacology
ISSN: 1365-2125
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