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Increased killer B cells in chronic HCV infection may lead to autoimmunity and increased viral load.

08:00 EDT 17th April 2018 | BioPortfolio

Summary of "Increased killer B cells in chronic HCV infection may lead to autoimmunity and increased viral load."

B regulatory (Breg) cells are characterized by various membrane markers, and the secretion of different inhibitory cytokines. A new subset of Breg cells was identified as CD5hi Fas-ligand (FasL)hi. Their main reported role is to suppress anti-viral and anti-tumor immune responses and hence, they have been dubbed "killer" B cells. In this study, we aim to assess the role of these cells in chronic hepatitis C virus (HCV) infection, and determine if they contribute to the increased viral load and persistence of HCV and its related autoimmunity.

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Name: Clinical and experimental immunology
ISSN: 1365-2249
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