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Total Synthesis of (+)- and (±)-Hosieine A.

08:00 EDT 3rd May 2018 | BioPortfolio

Summary of "Total Synthesis of (+)- and (±)-Hosieine A."

Described here is a concise total synthesis of the highly potent nicotinic acetylcholine receptor antagonist hosieine A in racemic ((±)-2) and enantioenriched ((+)-2) forms. The synthesis requires only 7-steps and features a telescoped reaction sequence initiated by a gold-catalyzed Rautenstrauch reaction.

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This article was published in the following journal.

Name: Angewandte Chemie (International ed. in English)
ISSN: 1521-3773
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