Shorter Time to Pregnancy With Increasing Preconception Carotene Concentrations Among Women With 1 to 2 Previous Pregnancy Losses.

08:00 EDT 14th May 2018 | BioPortfolio

Summary of "Shorter Time to Pregnancy With Increasing Preconception Carotene Concentrations Among Women With 1 to 2 Previous Pregnancy Losses."

Although maternal nutrition may impact fecundity, associations between preconception micronutrients and time to pregnancy (TTP) has not been examined. We assessed the relationship between preconception fat-soluble micronutrient concentrations and TTP among women with 1-2 prior pregnancy losses. This is a prospective cohort study of 1,228 women set in the EAGeR Trial (US, 2007-2011), which assessed the effect of preconception-initiated daily low dose aspirin on reproductive outcomes. We measured preconception zeaxanthin, cryptoxanthin, lycopene, α- and β-carotene, and α- and γ-tocopherol in serum. We used discrete Cox regression models, accounting for left truncation and right censoring, to calculate fecundability odds ratios (FOR) and 95% confidence intervals (CI). Models were adjusted for age, body mass index, race, smoking, alcohol, physical activity, income, vitamin use, cholesterol, treatment arm, and study site. Serum α-carotene levels (FOR = 1.17, 95%
1.00, 1.36, per log unit [μg/dL] increase), as well as concentrations above versus below the US average (2.92 μg/dL) were associated with shorter TTP (FOR = 1.21 95%
1.02, 1.44). Compared to below the US average (187 μg/dL), γ-tocopherol concentrations above the US average were associated with longer TTP (FOR = 0.83, 95%
0.69, 1.00). The potential for these nutrients to influence fecundability deserves further exploration.


Journal Details

This article was published in the following journal.

Name: American journal of epidemiology
ISSN: 1476-6256


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An organized and comprehensive program of health care that identifies and reduces a woman's reproductive risks before conception through risk assessment, health promotion, and interventions. Preconception care programs may be designed to include the male partner in providing counseling and educational information in preparation for fatherhood, such as genetic counseling and testing, financial and family planning, etc. This concept is different from PRENATAL CARE, which occurs during pregnancy.

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A carotenoid produced in most carotenogenic organisms. It is one of several sequentially synthesized molecules that are precursors to BETA CAROTENE.

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A monooxygenase that catalyzes the conversion of BETA-CAROTENE into two molecules of RETINAL. It was formerly characterized as EC and EC

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