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Altered tryptophan catabolite concentrations in major depressive disorder and associated changes in hippocampal subfield volumes.

08:00 EDT 19th May 2018 | BioPortfolio

Summary of "Altered tryptophan catabolite concentrations in major depressive disorder and associated changes in hippocampal subfield volumes."

Tryptophan depletion is a well-replicated biological finding in Major Depressive Disorder (MDD). The kynurenine pathway (KP) and its rate-limiting tryptophan degrading enzyme, indolamine 2,3 dioxygenase (IDO), have been implicated in the pathogenesis of depression. IDO expression is driven by inflammatory cytokines, providing a putative link between inflammation and neuropathology. This study examined circulating concentrations of C-reactive protein (CRP), plasma tryptophan, kynurenine (KYN), kynurenic acid (KYNA) and quinolinic acid (QUIN) and whole blood mRNA expression of IDO in patients with major depressive disorder (MDD) compared with healthy controls (HC).

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Journal Details

This article was published in the following journal.

Name: Psychoneuroendocrinology
ISSN: 1873-3360
Pages: 8-17

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