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Development of clinical-stage human monoclonal antibodies that treat advanced Ebola virus disease in non-human primates.

08:00 EDT 31st May 2018 | BioPortfolio

Summary of "Development of clinical-stage human monoclonal antibodies that treat advanced Ebola virus disease in non-human primates."

For most classes of drugs rapid development of therapeutics to treat emerging infections is challenged by the timelines needed to identify compounds with the desired efficacy, safety and PK profiles. Fully human monoclonal antibodies (mAbs) provide an attractive method to overcome many of these hurdles to rapidly produce therapeutics for emerging diseases.

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This article was published in the following journal.

Name: The Journal of infectious diseases
ISSN: 1537-6613
Pages:

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Medical and Biotech [MESH] Definitions

Antibodies from non-human species whose protein sequences have been modified to make them nearly identical with human antibodies. If the constant region and part of the variable region are replaced, they are called humanized. If only the constant region is modified they are called chimeric. INN names for humanized antibodies end in -zumab.

Antibodies obtained from a single clone of cells grown in mice or rats.

Antibodies produced by human or animal cells following clinical or experimental exposure to parasitic PROTOZOAN ANTIGENS.

Differentiation antigens residing on mammalian leukocytes. CD stands for cluster of differentiation, which refers to groups of monoclonal antibodies that show similar reactivity with certain subpopulations of antigens of a particular lineage or differentiation stage. The subpopulations of antigens are also known by the same CD designation.

Antibodies produced by clones of cells such as those isolated after hybridization of activated B LYMPHOCYTES with neoplastic cells. These hybrids are often referred to as HYBRIDOMAS.

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