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A multicenter survey of antimicrobial susceptibility of Prevotella species as determined by Etest methodology.

08:00 EDT 17th May 2018 | BioPortfolio

Summary of "A multicenter survey of antimicrobial susceptibility of Prevotella species as determined by Etest methodology."

Knowledge about the antimicrobial susceptibility patterns of different Prevotella species is limited. The aim of this study was to determine the current antimicrobial susceptibility of clinical isolates of Prevotella species from different parts of Europe, Kuwait and Turkey. Activity of 12 antimicrobials against 508 Prevotella isolates, representing 19 species, were tested according to Etest methodology. EUCAST, CLSI and FDA guidelines were used for susceptibility interpretations. All Prevotella species were susceptible to piperacillin/tazobactam, imipenem, meropenem, tigecycline and metronidazole. Ampicillin/sulbactam and cefoxitin also showed good activity. Ampicillin, clindamycin, tetracycline and moxifloxacin were less active; 51.2%, 33.7%, 36.8% and 18.3% of isolates were non-susceptible, respectively. A total of 49 (9.6%) isolates were resistant to three or more antimicrobials. Prevotella bivia was the most prevalent species (n = 118) and accounted for most of the multidrug-resistant isolates. In conclusion, the level of non-susceptibility to antimicrobials, which may be used for treatment of infections involving Prevotella species, are a cause of concern. This data emphasizes the need for species level identification of clinical Prevotella isolates and periodic monitoring of their susceptibility to guide empirical treatment.

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This article was published in the following journal.

Name: Anaerobe
ISSN: 1095-8274
Pages: 9-15

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A species of gram-negative bacteria in the family Prevotellaceae. It is the species most commonly isolated from endodontic infections (PULPITIS).

A saccharolytic species of gram-negative bacteria in the family Prevotellaceae. It ferments a wide range of CARBOHYDRATES in the RUMEN of animals.

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A phenotypic outcome (physical characteristic or disease predisposition) that is determined by more than one gene. Polygenic refers to those determined by many genes, while oligogenic refers to those determined by a few genes.

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