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In this study, we aimed to investigate the immunogenicity of cationic liposomes loaded with diphtheria toxoid (DT) and poly(
C) after hollow microneedle-mediated intradermal vaccination in mice. The following liposomal formulations were studied: DT loaded liposomes, a mixture of free DT and poly(
C)-loaded liposomes, a mixture of DT-loaded liposomes and free poly(
C), and liposomal formulations with DT and poly(
C) either individually or co-encapsulated in the liposomes. Reference groups were DT solution adjuvanted with or without poly(
C)). The liposomal formulations were characterized in terms of particle size, zeta potential, loading and release of DT and poly(
C). After intradermal injection of BALB/c mice with the formulations through a hollow microneedle, the immunogenicity was assessed by DT-specific ELISAs. All formulations induced similar total IgG and IgG1 titers. However, all the liposomal groups containing both DT and poly(
C) showed enhanced IgG2a titers compared to DT/poly(
C) solution, indicating that the immune response was skewed towards a Th1 direction. This enhancement was similar for all liposomal groups that contain both DT and poly(
C) in the formulations. Our results reveal that a mixture of DT encapsulated liposomes and poly(
C) encapsulated liposomes have a similar effect on the antibody responses as DT and poly(
C) co-encapsulated liposomes. These findings may have implications for future design of liposomal vaccine delivery systems.
This article was published in the following journal.
Name: International journal of pharmaceutics
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The formaldehyde-inactivated toxin of Corynebacterium diphtheriae. It is generally used in mixtures with TETANUS TOXOID and PERTUSSIS VACCINE; (DTP); or with tetanus toxoid alone (DT for pediatric use and Td, which contains 5- to 10-fold less diphtheria toxoid, for other use). Diphtheria toxoid is used for the prevention of diphtheria; DIPHTHERIA ANTITOXIN is for treatment.
A vaccine consisting of DIPHTHERIA TOXOID; TETANUS TOXOID; and whole-cell PERTUSSIS VACCINE. The vaccine protects against diphtheria, tetanus, and whooping cough.
Combined vaccines consisting of DIPHTHERIA TOXOID; TETANUS TOXOID; and an acellular form of PERTUSSIS VACCINE. At least five different purified antigens of B. pertussis have been used in various combinations in these vaccines.
A combined vaccine used to prevent infection with diphtheria and tetanus toxoid. This is used in place of DTP vaccine (DIPHTHERIA-TETANUS-PERTUSSIS VACCINE) when PERTUSSIS VACCINE is contraindicated.
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