Meiosis: SUMO Keeps a Tight Grip on Sister Chromatids.

08:00 EDT 4th June 2018 | BioPortfolio

Summary of "Meiosis: SUMO Keeps a Tight Grip on Sister Chromatids."

Maintaining cohesion between sister chromatids during the first meiotic cell division is crucial for preventing oocyte aneuploidy. In a new paper in Current Biology, Yi and colleagues present evidence that the Small Ubiquitin-related Modifier (SUMO) pathway protects centromeric sister cohesion during the meiosis I-II transition in mouse oocytes.


Journal Details

This article was published in the following journal.

Name: Current biology : CB
ISSN: 1879-0445
Pages: R671-R674


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Medical and Biotech [MESH] Definitions

An exchange of segments between the sister chromatids of a chromosome, either between the sister chromatids of a meiotic tetrad or between the sister chromatids of a duplicated somatic chromosome. Its frequency is increased by ultraviolet and ionizing radiation and other mutagenic agents and is particularly high in BLOOM SYNDROME.

Either of the two longitudinally adjacent threads formed when a eukaryotic chromosome replicates prior to mitosis. The chromatids are held together at the centromere. Sister chromatids are derived from the same chromosome. (Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)

The failure of homologous CHROMOSOMES or CHROMATIDS to segregate during MITOSIS or MEIOSIS with the result that one daughter cell has both of a pair of parental chromosomes or chromatids and the other has none.

Repair of DNA DAMAGE by exchange of DNA between matching sequences, usually between the allelic DNA (ALLELES) of sister chromatids.

The sites in a dividing cell where the minus ends of the spindle MICROTUBULES assemble and where the separated sister CHROMATIDS converge.

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