MiR-182 promotes glucose metabolism by upregulating hypoxia-inducible factor 1α in NSCLC cells.

08:00 EDT 9th June 2018 | BioPortfolio

Summary of "MiR-182 promotes glucose metabolism by upregulating hypoxia-inducible factor 1α in NSCLC cells."

This study aims to demonstrate the role of miR-182 in the glucose metabolism of NSCLC cells and the potential mechanism.


Journal Details

This article was published in the following journal.

Name: Biochemical and biophysical research communications
ISSN: 1090-2104


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Medical and Biotech [MESH] Definitions

Dioxygenase enzymes that specifically hydroxylate a PROLINE residue on the HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT. They are OXYGEN-dependent enzymes that play an important role in mediating cellular adaptive responses to HYPOXIA.

A basic helix-loop-helix transcription factor that plays a role in APOPTOSIS. It is composed of two subunits: ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR and HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT.

Hypoxia-inducible factor 1, alpha subunit is a basic helix-loop-helix transcription factor that is regulated by OXYGEN availability and is targeted for degradation by VHL TUMOR SUPPRESSOR PROTEIN.

A ubiquitin-protein ligase that mediates OXYGEN-dependent polyubiquitination of HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT. It is inactivated in VON HIPPEL-LINDAU SYNDROME.

Maintenance of a constant blood glucose level by perfusion or infusion with glucose or insulin. It is used for the study of metabolic rates (e.g., in glucose, lipid, amino acid metabolism) at constant glucose concentration.

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