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Automated GMP-production of α- CMethyl-L-tryptophan using a tracer production system (TPS).

08:00 EDT 14th June 2018 | BioPortfolio

Summary of "Automated GMP-production of α- CMethyl-L-tryptophan using a tracer production system (TPS)."

The radiosynthesis and GMP validation of [ C] AMT for human use is described. Three consecutive batches were produced giving 940-3790 MBq (4-17% RCY, decay corrected, based on [ C]CO ). The molar activity at the end of synthesis was 19-35 GBq/μmol, the radiochemical purity was ≥98% and the enantiomeric purity was >99%. While the synthesis method was automated using a new generation of synthesis equipment, Tracer Production System (TPS) developed in house, the method should be readily applicable to other synthesis platforms with minor modifications.

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This article was published in the following journal.

Name: Journal of labelled compounds & radiopharmaceuticals
ISSN: 1099-1344
Pages:

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