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The radiosynthesis and GMP validation of [ C] AMT for human use is described. Three consecutive batches were produced giving 940-3790 MBq (4-17% RCY, decay corrected, based on [ C]CO ). The molar activity at the end of synthesis was 19-35 GBq/μmol, the radiochemical purity was ≥98% and the enantiomeric purity was >99%. While the synthesis method was automated using a new generation of synthesis equipment, Tracer Production System (TPS) developed in house, the method should be readily applicable to other synthesis platforms with minor modifications.
This article was published in the following journal.
Name: Journal of labelled compounds & radiopharmaceuticals
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Some aspirin-treated patients have a blunted pharmacological response predisposing to clinical failure. The investigators hypothesize that the blunted response often results from increased...
Production of drugs or biologicals which are unlikely to be manufactured by private industry unless special incentives are provided by others.
The science and practice of cultivating PLANTS that have economic value to man. It includes plant breeding, seed production, weeding, use of fertilizers, harvesting, storage, transportation, and marketing.
"The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.
A system of government in which means of production and distribution of goods are controlled by the state.
Heat production, or its measurement, of an organism at the lowest level of cell chemistry in an inactive, awake, fasting state. It may be determined directly by means of a calorimeter or indirectly by calculating the heat production from an analysis of the end products of oxidation within the organism or from the amount of oxygen utilized.