Automated GMP-production of α- CMethyl-L-tryptophan using a tracer production system (TPS).

08:00 EDT 14th June 2018 | BioPortfolio

Summary of "Automated GMP-production of α- CMethyl-L-tryptophan using a tracer production system (TPS)."

The radiosynthesis and GMP validation of [ C] AMT for human use is described. Three consecutive batches were produced giving 940-3790 MBq (4-17% RCY, decay corrected, based on [ C]CO ). The molar activity at the end of synthesis was 19-35 GBq/μmol, the radiochemical purity was ≥98% and the enantiomeric purity was >99%. While the synthesis method was automated using a new generation of synthesis equipment, Tracer Production System (TPS) developed in house, the method should be readily applicable to other synthesis platforms with minor modifications.


Journal Details

This article was published in the following journal.

Name: Journal of labelled compounds & radiopharmaceuticals
ISSN: 1099-1344


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