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A Fixed versus Weight-Based Dosing Strategy of Daptomycin may Improve Safety in Obese Adults.

08:00 EDT 15th June 2018 | BioPortfolio

Summary of "A Fixed versus Weight-Based Dosing Strategy of Daptomycin may Improve Safety in Obese Adults."

To compare daptomycin exposures and predicted safety outcomes with a simulated weight-based and fixed dose in morbidly-obese and non-obese subjects
METHODS:
We performed a nonparametric population pharmacokinetic analysis of daptomycin concentration-time data from a prior obese and non-obese kidney function matched cohort of healthy adult volunteers. Monte Carlo simulations were performed to compare the maximum concentrations (C ), minimum concentrations (C ), and area under the curve (AUC) with the standard daptomycin 6-mg/kg/day dose or a 500-mg daily fixed dose in obese and non-obese subjects. The probability of exceeding a daptomycin C target (≥ 24.3 mg/L) associated with creatine phosphokinase (CPK) elevations was computed with the two regimens.

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Journal Details

This article was published in the following journal.

Name: Pharmacotherapy
ISSN: 1875-9114
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Obesity
Obesity is the condition in which excess fat has accumulated in the body (mostly in subcutaneous tissues). clinical obesity is considered to be present when a person has a BMI of over 30 (Oxford Dictionary of Medicine). It is becoming increasing common i...


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