Advertisement

Topics

Leveraging GWAS for complex traits to detect signatures of natural selection in humans.

08:00 EDT 15th June 2018 | BioPortfolio

Summary of "Leveraging GWAS for complex traits to detect signatures of natural selection in humans."

Natural selection can shape the genetic architecture of complex traits. In human populations, signals of positive selection at genetic loci have been detected through a variety of genome-wide scanning approaches without the knowledge of how genes affect traits or fitness. In the past decade, genome-wide association studies (GWAS) have provided unprecedented insights into the genetic basis of quantitative variation in complex traits. Summary statistics generated from these GWAS have been shown to be an extraordinary data source that can be utilized to detect and quantify natural selection in the genetic architecture of complex traits. In this review, we focus on recent discoveries about selection on genetic variants associated with human complex traits based on GWAS-facilitated methods.

Affiliation

Journal Details

This article was published in the following journal.

Name: Current opinion in genetics & development
ISSN: 1879-0380
Pages: 9-14

Links

DeepDyve research library

PubMed Articles [12486 Associated PubMed Articles listed on BioPortfolio]

Deep whole-genome sequencing reveals recent selection signatures linked to evolution and disease risk of Japanese.

Understanding natural selection is crucial to unveiling evolution of modern humans. Here, we report natural selection signatures in the Japanese population using 2234 high-depth whole-genome sequence ...

Symposium review: Genetics, genome-wide association study, and genetic improvement of dairy fertility traits.

Before fertility traits were incorporated into selection, dairy cattle breeding primarily focused on production traits, which resulted in an unfavorable decline in the reproductive performance of dair...

Phenotype-Specific Enrichment of Mendelian Disorder Genes near GWAS Regions across 62 Complex Traits.

Although recent studies provide evidence for a common genetic basis between complex traits and Mendelian disorders, a thorough quantification of their overlap in a phenotype-specific manner remains el...

Genome-Wide Association Studies of Image Traits Reveal the Genetic Architecture of Drought Resistance in Rice.

Understanding how plants respond to drought can benefit drought resistance (DR) breeding. Using a non-destructive phenotyping facility, 51 image-based traits (i-traits) for 507 rice accessions were ex...

A population genetic interpretation of GWAS findings for human quantitative traits.

Human genome-wide association studies (GWASs) are revealing the genetic architecture of anthropomorphic and biomedical traits, i.e., the frequencies and effect sizes of variants that contribute to her...

Clinical Trials [3692 Associated Clinical Trials listed on BioPortfolio]

Natural Versus Synthetic Vitamin B Complexes in Human

In a cross-over study the investigators evaluate the effects of natural (Panmol-B-Complex) versus synthetic vitamin B complexes to identify the bioavailability of distinct vitamins as well...

Novel Approaches in Linkage Analysis for Complex Traits

To develop new statistical methods to explore genetic mechanisms that contribute to the development of hypertension.

Genetic Factors and Interrelationships for Cancer Risk-Related Behaviors and Complex Traits

We propose to conduct a multifactorial genetic study of cancer risk-related behaviors and other complex human characteristics. The main areas of interest are tobacco smoking, excess alcoh...

Metabolic Signatures and Biomarkers

We plan to use this platform to map biochemical signatures in unmedicated schizophrenic patients prior to and 4 weeks post treatment with the antipsychotic drug aripiprazole and compare th...

Genetic Study of Peginterferon Treatment in Hepatitis B Patients: The GIANT-B Study

Background and rationale Chronic hepatitis B is the most common cause of liver cirrhosis and hepatocellular carcinoma worldwide.(1) Antiviral therapy with oral nucleoside analogs and inter...

Medical and Biotech [MESH] Definitions

The selection or choice of sexual partner in animals. Often this reproductive preference is based on traits in the potential mate, such as coloration, size, or behavioral boldness. If the chosen ones are genetically different from the rejected ones, then NATURAL SELECTION is occurring.

The ability to detect sharp boundaries (stimuli) and to detect slight changes in luminance at regions without distinct contours. Psychophysical measurements of this visual function are used to evaluate visual acuity and to detect eye disease.

A deep blue dye (with the formula OC6H4NC6H4OH) used to detect AMMONIA in a common test called the Berthelot's reaction and to detect PARACETAMOL by spectrophotometry.

The leveraging of collective wisdom within an organization as a catalyst to increase responsiveness and innovation.

Adverse of favorable selection bias exhibited by insurers or enrollees resulting in disproportionate enrollment of certain groups of people.

Advertisement
Quick Search
Advertisement
Advertisement

 


DeepDyve research library

Relevant Topic

Bioinformatics
Bioinformatics is the application of computer software and hardware to the management of biological data to create useful information. Computers are used to gather, store, analyze and integrate biological and genetic information which can then be applied...


Searches Linking to this Article