Immunosuppressive drug therapy for preventing rejection following lung transplantation in cystic fibrosis.

08:00 EDT 18th June 2018 | BioPortfolio

Summary of "Immunosuppressive drug therapy for preventing rejection following lung transplantation in cystic fibrosis."

For people with cystic fibrosis and advanced pulmonary damage, lung transplantation is an available and viable option. However, graft rejection is an important potential consequence after lung transplantation. Immunosuppressive therapy is needed to prevent episodes of graft rejection and thus subsequently reduce morbidity and mortality in this population. There are a number of classes of immunosuppressive drugs which act on different components of the immune system. There is considerable variability in the use of immunosuppressive agents after lung transplantation in cystic fibrosis. While much of the research in immunosuppressive drug therapy has focused on the general population of lung transplant recipients, little is known about the comparative effectiveness and safety of these agents in people with cystic fibrosis. This is an update of a previously published review.


Journal Details

This article was published in the following journal.

Name: The Cochrane database of systematic reviews
ISSN: 1469-493X
Pages: CD009421


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Medical and Biotech [MESH] Definitions

Manipulation of the host's immune system in treatment of disease. It includes both active and passive immunization as well as immunosuppressive therapy to prevent graft rejection.

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A form of ischemia-reperfusion injury occurring in the early period following transplantation. Significant pathophysiological changes in MITOCHONDRIA are the main cause of the dysfunction. It is most often seen in the transplanted lung, liver, or kidney and can lead to GRAFT REJECTION.

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