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The road map towards an HCV-free transplant population.

08:00 EDT 23rd June 2018 | BioPortfolio

Summary of "The road map towards an HCV-free transplant population."

Antiviral therapy to eradicate hepatitis C virus (HCV) infection improves outcomes in patients undergoing liver transplantation (LT) for advanced chronic HCV with or without hepatocellular carcinoma. Traditionally, antiviral therapy focused on the use of interferon (IFN)-based regimens, with antiviral treatment initiated in the post-transplant period once recurrent HCV disease with fibrosis in the allograft was identified. The use of IFN-based therapy was limited in pre-transplant patients with advanced liver disease. Earlier intervention, either before transplantation or early after LT is now feasible with the advent of second-generation direct-acting antiviral agents (DAAs) with superior tolerability and efficacy to IFN-based therapy. These agents have the potential to reduce the number of patients developing HCV-related complications requiring LT and re-transplantation, as well as reducing the demand for donor organs. We discuss the pros and cons of pre-transplant, peri-transplant and post-transplant therapy with current DAAs, citing available data from clinical trials and real-world experience. This article is protected by copyright. All rights reserved.

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This article was published in the following journal.

Name: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
ISSN: 1600-6143
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