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Antiviral therapy to eradicate hepatitis C virus (HCV) infection improves outcomes in patients undergoing liver transplantation (LT) for advanced chronic HCV with or without hepatocellular carcinoma. Traditionally, antiviral therapy focused on the use of interferon (IFN)-based regimens, with antiviral treatment initiated in the post-transplant period once recurrent HCV disease with fibrosis in the allograft was identified. The use of IFN-based therapy was limited in pre-transplant patients with advanced liver disease. Earlier intervention, either before transplantation or early after LT is now feasible with the advent of second-generation direct-acting antiviral agents (DAAs) with superior tolerability and efficacy to IFN-based therapy. These agents have the potential to reduce the number of patients developing HCV-related complications requiring LT and re-transplantation, as well as reducing the demand for donor organs. We discuss the pros and cons of pre-transplant, peri-transplant and post-transplant therapy with current DAAs, citing available data from clinical trials and real-world experience. This article is protected by copyright. All rights reserved.
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Motorized, recreational vehicles used on non-public roads. They include all-terrain vehicles, dirt-bikes, minibikes, motorbikes, trailbikes, and snowmobiles. Excludes MOTORCYCLES, which are considered public road vehicles.
Ongoing scrutiny of a population (general population, study population, target population, etc.), generally using methods distinguished by their practicability, uniformity, and frequently their rapidity, rather than by complete accuracy.
Differences in measurable biological values, characteristics, or traits, among individuals of a population or between population groups.
The number of new cases of a given disease during a given period in a specified population. It also is used for the rate at which new events occur in a defined population. It is differentiated from PREVALENCE, which refers to all cases, new or old, in the population at a given time.
Morphological or behavioral traits influenced by various living conditions that a population encounters especially as it pertains to REPRODUCTION and survival of the population (see POPULATION DYNAMICS) such as age at first reproductive event, number and size of offspring, and lifespan.
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