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Short-term exposure of human sebocytes to 13-cis retinoic acid induces acnegenic changes.

08:00 EDT 23rd June 2018 | BioPortfolio

Summary of "Short-term exposure of human sebocytes to 13-cis retinoic acid induces acnegenic changes."

Acne vulgaris is the most common skin disorder and contributes an estimated 0.29% of the global burden of disease. The pathophysiology of acne involves excess sebum production and altered lipid composition by the sebaceous glands, follicular hyperkeratinization, bacterial colonization by Cutibacterium acnes (C. acnes), and perifollicular inflammation. 13-cis Retinoic Acid (13-cis RA), also known as isotretinoin, is the only acne therapy that targets all four pathologic mechanisms and is often prescribed to patients with severe acne. This article is protected by copyright. All rights reserved.

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This article was published in the following journal.

Name: The British journal of dermatology
ISSN: 1365-2133
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Medical and Biotech [MESH] Definitions

Proteins in the nucleus or cytoplasm that specifically bind RETINOIC ACID or RETINOL and trigger changes in the behavior of cells. Retinoic acid receptors, like steroid receptors, are ligand-activated transcription regulators. Several types have been recognized.

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