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The structural basis for filovirus neutralization by monoclonal antibodies.

08:00 EDT 22nd June 2018 | BioPortfolio

Summary of "The structural basis for filovirus neutralization by monoclonal antibodies."

Filoviruses, including ebolaviruses and marburgviruses, are the causative agents of highly lethal disease outbreaks. The 2013-2016 Ebola virus outbreak was responsible for >28000 infections and >11000 deaths. Although there are currently no licensed vaccines or therapeutics for any filovirus-induced disease, monoclonal antibodies (mAbs) are among the most promising options for therapeutic development. Hundreds of mAbs have been isolated from human survivors of filovirus infections that target the viral spike glycoprotein (GP). The binding, neutralization, and cross-reactivity of many of these mAbs has been determined. Several mAbs have been characterized structurally, and this information has been crucial for strategizing therapeutic and vaccine design. Here we present an overview of the structural features of the neutralizing/protective epitopes on filovirus glycoproteins.

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This article was published in the following journal.

Name: Current opinion in immunology
ISSN: 1879-0372
Pages: 196-202

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