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Genetic Variants with Gene Regulatory Effects are Associated with Diisocyanate Asthma.

08:00 EDT 30th June 2018 | BioPortfolio

Summary of "Genetic Variants with Gene Regulatory Effects are Associated with Diisocyanate Asthma."

Isocyanates are major causes of occupational asthma but susceptibility and mechanisms of Diisocyanate Asthma (DA) remain uncertain.

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This article was published in the following journal.

Name: The Journal of allergy and clinical immunology
ISSN: 1097-6825
Pages:

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Medical and Biotech [MESH] Definitions

The GENETIC RECOMBINATION of the parts of two or more GENES resulting in a gene with different or additional regulatory regions, or a new chimeric gene product. ONCOGENE FUSION includes an ONCOGENE as at least one of the fusion partners and such gene fusions are often detected in neoplastic cells and are transcribed into ONCOGENE FUSION PROTEINS. ARTIFICIAL GENE FUSION is carried out in vitro by RECOMBINANT DNA technology.

Nucleotide sequences of a gene that are involved in the regulation of GENETIC TRANSCRIPTION.

Techniques used to add in exogenous gene sequence such as mutated genes; REPORTER GENES, to study mechanisms of gene expression; or regulatory control sequences, to study effects of temporal changes to GENE EXPRESSION.

The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.

The effects on gene expression that depend on the location of a gene with respect to its neighboring genes and region of chromosome. Stable position effects are sequence dependent. Variegated position effects depend on whether the gene is located in or adjacent to HETEROCHROMATIN or EUCHROMATIN.

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