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Impact of bitter taste receptor phenotype upon clinical presentation in chronic rhinosinusitis.

08:00 EDT 4th July 2018 | BioPortfolio

Summary of "Impact of bitter taste receptor phenotype upon clinical presentation in chronic rhinosinusitis."

Genetic variation of the bitter taste receptor T2R38 has been associated with recalcitrant chronic rhinosinusitis (CRS). Specific T2R38 polymorphisms, correlating with bitter taste sensitivity to phenylthiocarbamide (PTC), have been identified as an independent risk factor for surgical intervention in CRS patients without polyps; however, the exact role of PTC tasting ability in clinical practice remains unknown. In this investigation we characterize PTC taste sensitivity in a tertiary care rhinology practice with pertinent clinical measures of disease and quality of life (QOL).

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This article was published in the following journal.

Name: International forum of allergy & rhinology
ISSN: 2042-6984
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A purinergic P2X neurotransmitter receptor involved in sensory signaling of TASTE PERCEPTION, chemoreception, visceral distension, and NEUROPATHIC PAIN. The receptor comprises three P2X3 subunits. The P2X3 subunits are also associated with P2X2 RECEPTOR subunits in a heterotrimeric receptor variant.

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