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Pharmacokinetics of tiotropium in asthmatic children aged 6-11 years support its safety profile.

08:00 EDT 4th July 2018 | BioPortfolio

Summary of "Pharmacokinetics of tiotropium in asthmatic children aged 6-11 years support its safety profile."

The efficacy and safety of tiotropium Respimat , a long-acting muscarinic antagonist (LAMA), as add-on to maintenance inhaled corticosteroids (ICS), with or without additional controllers, has been demonstrated in children aged 6-11 and 12-17 years with symptomatic moderate and severe asthma (1-4). The pharmacokinetic (PK) properties of tiotropium have been reported in adult patients with chronic obstructive pulmonary disease (COPD) (5) and cystic fibrosis (6), and in adults and adolescents with asthma (7), but not in children. PK evaluation was intended to assess whether exposure to inhaled tiotropium in children aged 6-11 years with asthma is within the range observed in adults in order to further support its safety evaluation in this age group (7). This article is protected by copyright. All rights reserved.

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This article was published in the following journal.

Name: Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology
ISSN: 1399-3038
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