Synthesis of Secondary Amides from Thiocarbamates.

08:00 EDT 5th July 2018 | BioPortfolio

Summary of "Synthesis of Secondary Amides from Thiocarbamates."

The synthesis of secondary amides from readily accessible and bench-stable substituted S-phenyl thiocarbamates and Grignard reactants is reported. Oxidative workup allows recycling of the thiolate leaving group as diphenyl disulfide. Diphenyl disulfide can be transformed into S-phenyl benzenethiosulfonate, a reactant required for thiocarbamate synthesis. This amide synthesis is suitable for the preparation of challenging amides that are not or hardly accessible via classical approaches.


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Name: Organic letters
ISSN: 1523-7052


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