Use of apatinib combined with pemetrexed for advanced ovarian cancer: A case report.
Summary of "Use of apatinib combined with pemetrexed for advanced ovarian cancer: A case report."
Ovarian cancer is the most deadly gynecologic cancer, and the therapy is very difficult. Apatinib is a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor receptor-2. At present, there are few studies or case reports on apatinib treatment for patients with ovarian cancer.
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Journal Details
This article was published in the following journal.
Name: Medicine
ISSN: 1536-5964
Pages: e11036
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/29979376
- DOI: http://dx.doi.org/10.1097/MD.0000000000011036
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Medical and Biotech [MESH] Definitions
Hereditary Breast And Ovarian Cancer Syndrome
Autosomal dominant HEREDITARY CANCER SYNDROME in which a mutation most often in either BRCA1 or BRCA2 is associated with a significantly increased risk for breast and ovarian cancers.
Krukenberg Tumor
Mucocellular carcinoma of the ovary, usually metastatic from the gastrointestinal tract, characterized by areas of mucoid degeneration and the presence of signet-ring-like cells. It accounts for 30%-40% of metastatic cancers to the ovaries and possibly 1%-2% of all malignant ovarian tumors. The lesions may not be discovered until the primary disease is advanced, and most patients die of their disease within a year. In some cases, a primary tumor is not found. (From Dorland, 27th ed; Holland et al., Cancer Medicine, 3d ed, p1685)
Chemoradiotherapy, Adjuvant
Combined chemotherapy and radiotherapy given to augment some other form of treatment such as surgery. It is commonly used in the therapy of cancer.
Testolactone
An antineoplastic agent that is a derivative of progesterone and used to treat advanced breast cancer.
Topotecan
An antineoplastic agent used to treat ovarian cancer. It works by inhibiting DNA TOPOISOMERASES, TYPE I.
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