Nicotine metabolite ratio predicts smoking topography: The Pennsylvania Adult Smoking Study.

08:00 EDT 4th July 2018 | BioPortfolio

Summary of "Nicotine metabolite ratio predicts smoking topography: The Pennsylvania Adult Smoking Study."

The nicotine metabolite ratio (NMR) as measured by the ratio of 3'hydroxycotinine to cotinine has been examined in relation to tobacco use patterns including cigarettes per day and quit success to determine its role in nicotine dependence. We examined the NMR in relation to smoking topography and tested the hypothesis that normal metabolizers have a greater total daily puff volume than slow metabolizers.


Journal Details

This article was published in the following journal.

Name: Drug and alcohol dependence
ISSN: 1879-0046
Pages: 89-93


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Medical and Biotech [MESH] Definitions

The N-glucuronide conjugate of cotinine is a major urinary metabolite of NICOTINE. It thus serves as a biomarker of exposure to tobacco SMOKING. It has CNS stimulating properties.

SMOKING of non-TOBACCO (or NICOTINE-containing) substances.


A plant genus of the family SOLANACEAE. Members contain NICOTINE and other biologically active chemicals; its dried leaves are used for SMOKING.

Nicotine is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Nicotine is also important medically because of its presence in tobacco smoke.

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