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Certolizumab pegol in the treatment of Takayasu arteritis.

08:00 EDT 12th July 2018 | BioPortfolio

Summary of "Certolizumab pegol in the treatment of Takayasu arteritis."

Certolizumab pegol (CZP) is a PEGylated antigen-binding fragment-fragment of a humanized mAb neutralizing TNF. It lacks Fc-fragment and has a very low potential to cross the placenta. We aimed to report the efficacy and safety of CZP in a case series of patients with refractory Takayasu arteritis (TA).

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This article was published in the following journal.

Name: Rheumatology (Oxford, England)
ISSN: 1462-0332
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Medical and Biotech [MESH] Definitions

A polyethylene-glycolated Fab' fragment of TUMOR NECROSIS FACTOR antibody that binds specifically to TNF-ALPHA and neutralises it in a dose-dependent manner. It also inhibits the production of lipopolysaccharide-induced TNF-ALPHA and IL-1 BETA and is used to treat RHEUMATOID ARTHRITIS and PSORIATIC ARTHRITIS.

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INFLAMMATION of any ARTERIES.

A genus of the family ARTERIVIRIDAE, in the order NIDOVIRALES. The type species is ARTERITIS VIRUS, EQUINE.

The type species of the genus ARTERIVIRUS and the etiologic agent of an important equine respiratory disease causing abortion, pneumonia, or other infections.

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