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Age and Sex Are Critical Factors in Ischemic Stroke Pathology.

08:00 EDT 11th July 2018 | BioPortfolio

Summary of "Age and Sex Are Critical Factors in Ischemic Stroke Pathology."

Ischemic stroke is a devastating brain injury, resulting in high mortality and significant loss-of-function. Understanding the pathophysiology of ischemic stroke risk, mortality and functional loss is critical to novel therapeutic development. Age and sex have a complex and interactive effect on ischemic stroke risk and pathophysiology. Aging is the strongest non-modifiable risk factor for ischemic stroke, and aged stroke patients have higher mortality, morbidity and poorer functional recovery than their young counterparts. Importantly, patient age modifies the influence of patient sex in ischemic stroke. Early in life, the burden of ischemic stroke is higher in males, but becomes more common and debilitating for women in elderly populations. The profound effects of sex and age on clinical ischemic stroke are mirrored in the results of experimental in vivo and in vitro studies. Here, we will review current knowledge on the influence of age and sex in ischemic stroke incidence, mortality and functional outcome in clinical populations. We will also discuss the experimental evidence for sex- and age- differences in stroke pathophysiology, and how a better understanding of these biological variables can improve clinical care and enhance novel therapeutic development.

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This article was published in the following journal.

Name: Endocrinology
ISSN: 1945-7170
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