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Reactive Oxygen Species in Seminal Plasma as a Cause of Male Infertility.

08:00 EDT 14th July 2018 | BioPortfolio

Summary of "Reactive Oxygen Species in Seminal Plasma as a Cause of Male Infertility."

Male factor is responsible for 40-50% of infertility cases, contributing equally as a female factor. Oxidative stress has now emerged as one of the major causes of unexplained male infertility, as it leads to increased risk of Deoxyribonucleic acid (DNA) fragmentation, decreased sperm motility, concentration and abnormal morphology. Though a certain amount of reactive oxygen species (ROS) activity is essential for normal functioning of sperms, an excess lead to pathological effects on semen parameters, ultimately resulting in male sub-fertility or infertility. Furthermore, oxidative stress affected sperm cells with damaged DNA result in increased risk of birth defects, neuropsychiatric problems and cancers in off-springs of such fathers due to increased risk of de-novo mutations in the germline and post-fertilization. Hence, present review helps in highlighting the facts about ROS, their production, physiological functions and pathological effects on sperm dysfunction and DNA damage, leading to male infertility.

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This article was published in the following journal.

Name: Journal of gynecology obstetrics and human reproduction
ISSN: 2468-7847
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Medical and Biotech [MESH] Definitions

Proteins found in SEMEN. Major seminal plasma proteins are secretory proteins from the male sex accessory glands, such as the SEMINAL VESICLES and the PROSTATE. They include the seminal vesicle-specific antigen, an ejaculate clotting protein; and the PROSTATE-SPECIFIC ANTIGEN, a protease and an esterase.

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