Diagnosis, treatment and prophylaxis of malaria in the Czech Republic.

07:00 EST 1st March 2018 | BioPortfolio

Summary of "Diagnosis, treatment and prophylaxis of malaria in the Czech Republic."

Malaria represents the most important parasitic infection imported from the tropics causing death in 1-2 % of travelers with this diagnosis. Around 30 cases of malaria are diagnosed in the Czech Republic every year. Fever is the most common clinical presentation. The most severe forms of malaria are caused by Plasmodium falciparum. The diagnosis of malaria is based on examination of stained thick and thin blood smears. This method enables determination of Plasmodium species and parasite count. The treatment of ma-laria has to be initiated immediately after the laboratory confirmation. In the Czech Republic, uncomplicated falciparum malaria is treated by oral administration of artemether/lumefantrine or atovaquone/proguanil. Complicated falciparum malaria is treated by parenteral administration of quinine in combination with clindamycin. For the chemoprophylaxis of malaria in travelers to the highly endemic regions, atovaquone/proguanil, doxycycline or mefloquine are recommended.


Journal Details

This article was published in the following journal.

Name: Klinicka mikrobiologie a infekcni lekarstvi
ISSN: 1211-264X
Pages: 20-30


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Medical and Biotech [MESH] Definitions

Created 1 January 1993 as a result of the division of Czechoslovakia into the Czech Republic and Slovakia.

Created as a republic in 1918 by Czechs and Slovaks from territories formerly part of the Austro-Hungarian Empire. The country split into the Czech Republic and Slovakia 1 January 1993.

A biguanide compound which has little antimalarial activity until metabolized in the body to the active antimalarial agent cycloguanil. The usefulness of proguanil is limited by the rapid development of drug resistance by the malarial parasite. The hydrochloride is used for the casual prophylaxis of falciparum malaria, to suppress other forms of malaria, and to reduce transmission of infection (From Martindale, The Extra Pharmacopoeia, 30th ed, p405)

Created 1 January 1993 as a result of the division of Czechoslovakia into the Czech Republic and Slovakia.

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