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A Continuously Regenerable Chiral Ammonia Borane for Asymmetric Transfer Hydrogenations.

08:00 EDT 18th July 2018 | BioPortfolio

Summary of "A Continuously Regenerable Chiral Ammonia Borane for Asymmetric Transfer Hydrogenations."

A novel chiral ammonia borane was designed and developed via the dehydrogenation of ammonia borane with chiral phosphoric acid, which was highly effective for the asymmetric transfer hydrogenation of imines and β-enamino esters to afford high levels of reactivities and enantioselectivies. Significantly, this chiral ammonia borane can be continuously regenerated during the transfer hydrogenation with the assistance of water and ammonia borane, which allowed as low as 0.1 mol % of chiral phosphoric acid to give satisfactory results. Notably, the role of chiral phosphoric acid is to produce the chiral ammonia borane.

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This article was published in the following journal.

Name: Angewandte Chemie (International ed. in English)
ISSN: 1521-3773
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