Drug capture materials based on genomic DNA-functionalized magnetic nanoparticles.

08:00 EDT 20th July 2018 | BioPortfolio

Summary of "Drug capture materials based on genomic DNA-functionalized magnetic nanoparticles."

Chemotherapy agents are notorious for producing severe side-effects. One approach to mitigating this off-target damage is to deliver the chemotherapy directly to a tumor via transarterial infusion, or similar procedures, and then sequestering any chemotherapeutic in the veins draining the target organ before it enters the systemic circulation. Materials capable of such drug capture are yet to be fully realized. Here, we report the covalent attachment of genomic DNA to iron-oxide nanoparticles. With these magnetic materials, we captured three common chemotherapy agents-doxorubicin, cisplatin, and epirubicin-from biological solutions. We achieved 98% capture of doxorubicin from human serum in 10 min. We further demonstrate that DNA-coated particles can rescue cultured cardiac myoblasts from lethal levels of doxorubicin. Finally, the in vivo efficacy of these materials was demonstrated in a porcine model. The efficacy of these materials demonstrates the viability of genomic DNA-coated materials as substrates for drug capture applications.


Journal Details

This article was published in the following journal.

Name: Nature communications
ISSN: 2041-1723
Pages: 2870


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