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An Alternative Intermittent Eltrombopag Dosing Protocol for Treatment of Chronic Immune Thrombocytopenia.

08:00 EDT 22nd July 2018 | BioPortfolio

Summary of "An Alternative Intermittent Eltrombopag Dosing Protocol for Treatment of Chronic Immune Thrombocytopenia."

Eltrombopag, an oral thrombopoietin receptor agonist, is dosed daily to treat chronic immune thrombocytopenia (ITP). Because it has a half-life of 26-35 hours in ITP patients and strict dietary restrictions that may impair quality of life and reduce compliance, we developed an alternative intermittent (AI) eltrombopag dosing protocol for ITP with dosing less frequently than once daily. Ten patients were treated with AI dosing for a median of 94 (range: 29-156) weeks, with most patients treated with 2-4 weekly doses for extended durations. During AI dosing, 95%, 84% and 71% of all platelet counts were ≥20x10 /L, ≥50x10 /L and ≥100x10 /L, respectively. Five patients required rescue treatment for thrombocytopenia and WHO grade 1 mucocutaneous bleeding, and there were no thromboembolic events. In summary, intermittently dosed eltrombopag was efficacious in treating chronic ITP in a small cohort, with rates of platelet response and rescue treatment comparable to rates in studies evaluating daily dosing.

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Name: British journal of clinical pharmacology
ISSN: 1365-2125
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