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Umpolung Reactivity of Aldehydes toward Carbon Dioxide.

08:00 EDT 23rd July 2018 | BioPortfolio

Summary of "Umpolung Reactivity of Aldehydes toward Carbon Dioxide."

Carbon dioxide is an intrinsically stable molecule. Therefore, its activation requires extra energy input in the form of reactive reagents and/or activated catalysts and, often, harsh reaction conditions. We report here a direct carboxylation reaction of aromatic aldehydes with carbon dioxide, to afford α-keto acids as added-value products. In situ generation of a reactive cyanohydrin was key to the successful carboxylation reaction under operationally mild reaction conditions (25-40 oC, 1 atm CO2). The resulting α-keto acids served as a platform for alpha-amino acid synthesis via reductive amination reactions, illustrating the chemical synthesis of essential bioactive molecules from carbon dioxide.

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This article was published in the following journal.

Name: Angewandte Chemie (International ed. in English)
ISSN: 1521-3773
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