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Human Polyclonal Antibodies Produced by Transchromosomal Cattle Provide Partial Protection Against Lethal Zaire Ebolavirus Challenge in Rhesus Macaques.

08:00 EDT 25th July 2018 | BioPortfolio

Summary of "Human Polyclonal Antibodies Produced by Transchromosomal Cattle Provide Partial Protection Against Lethal Zaire Ebolavirus Challenge in Rhesus Macaques."

Antibody therapy has been used to treat a variety of diseases and the success of ZMapp and other monoclonal antibody-based therapies during the 2014-2016 West African Ebola outbreak has shown this countermeasure can be a successful therapy for Ebola hemorrhagic fever. This study utilized transchromosomal bovines (TcB) vaccinated with a DNA plasmid encoding Ebola virus glycoprotein sequence to produce human polyclonal antibodies directed against Ebola virus glycoprotein. When administered 1 day postinfection, these TcB polyclonal antibodies provided partial protection and resulted in a 50% survival rate following a lethal challenge of Ebola virus Makona in rhesus macaques.

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This article was published in the following journal.

Name: The Journal of infectious diseases
ISSN: 1537-6613
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Medical and Biotech [MESH] Definitions

Antibodies produced by human or animal cells following clinical or experimental exposure to parasitic PROTOZOAN ANTIGENS.

Antibodies produced by human or animal cells following clinical or experimental exposure to parasitic HELMINTH ANTIGENS. The IMMUNOGLOBULIN E class of immunoglobulins is usually formed and released, but IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; and IMMUNOGLOBULIN A may also occur.

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Recombinant antibodies produced in TRANSGENIC PLANTS. The plants serve as BIOREACTORS to produce the antibodies for medical use or industrial processes.

Antibodies produced by clones of cells such as those isolated after hybridization of activated B LYMPHOCYTES with neoplastic cells. These hybrids are often referred to as HYBRIDOMAS.

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