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Development of Triglyceride-Lowering Drugs to Address Residual Cardiovascular Risk Strategic and Clinical Considerations.

08:00 EDT 27th July 2018 | BioPortfolio

Summary of "Development of Triglyceride-Lowering Drugs to Address Residual Cardiovascular Risk Strategic and Clinical Considerations."

The prevalence of hypertriglyceridemia is high and growing in several parts of the world. Hypertriglyceridemia has a well-defined association with the risk of atherosclerotic cardiovascular (CV) disease and thus represents a potential target for drugs aimed at mitigating CV events. So far, no triglyceride-lowering pharmacological strategy has succeeded in conclusively showing the ability to modify clinical outcomes. This article discusses strategic and clinical aspects of development of triglyceride-lowering drugs to address CV disease.

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This article was published in the following journal.

Name: European heart journal. Cardiovascular pharmacotherapy
ISSN: 2055-6845
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A class of lipoproteins of small size (4-13 nm) and dense (greater than 1.063 g/ml) particles. HDL lipoproteins, synthesized in the liver without a lipid core, accumulate cholesterol esters from peripheral tissues and transport them to the liver for re-utilization or elimination from the body (the reverse cholesterol transport). Their major protein component is APOLIPOPROTEIN A-I. HDL also shuttle APOLIPOPROTEINS C and APOLIPOPROTEINS E to and from triglyceride-rich lipoproteins during their catabolism. HDL plasma level has been inversely correlated with the risk of cardiovascular diseases.

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