Has the Age of Cytoreductive Nephrectomy come to an end?

08:00 EDT 2nd August 2018 | BioPortfolio

Summary of "Has the Age of Cytoreductive Nephrectomy come to an end?"

The CARMENA (Cancer du Rein Metastatique Nephrectomie et Antiangiogéniques) trial was a prospective, multicentre, open-label, phase 3 trial that randomly assigned patients with Memorial Sloan Kettering Cancer Center (MSKCC) intermediate or poor risk metastatic renal cell carcinoma (mRCC) to undergo cytoreductive nephrectomy (CNx) followed by sunitinib or to sunitinib alone without nephrectomy. The study was designed to test the non-inferiority of sunitinib alone with respect to the primary endpoint overall survival. Secondary endpoints included progression-free survival, objective response rate (percentage of patients with complete or partial response), clinical benefit (percentage of patients with complete or partial response or stable disease for more than 12 weeks), CNx in the sunitinib-alone group, postoperative morbidity and mortality, and safety.


Journal Details

This article was published in the following journal.

Name: Urology
ISSN: 1527-9995


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Medical and Biotech [MESH] Definitions

Excision of a kidney. (Dorland, 28th ed)

Abnormal intravascular leukocyte aggregation and clumping often seen in leukemia patients. The brain and lungs are the two most commonly affected organs. This acute syndrome requires aggressive cytoreductive modalities including chemotherapy and/or leukophoresis. It is differentiated from LEUKEMIC INFILTRATION which is a neoplastic process where leukemic cells invade organs.

Either a single or a single functioning kidney due to NEPHRECTOMY, birth defects or other kidney diseases.

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