Skewed balance of regulatory T cell and inflammatory T cell in IL-17 defect with human metapneumovirus infection.

08:00 EDT 22nd June 2018 | BioPortfolio

Summary of "Skewed balance of regulatory T cell and inflammatory T cell in IL-17 defect with human metapneumovirus infection."

Human metapneumovirus (hMPV) is a common cause of respiratory infections in children. However, the precise mechanisms underlying the development of hMPV-induced pulmonary pathology remain unknown. Studies show that IL-17 plays an important role in some inflammatory diseases of the airways, including asthma and chronic obstructive pulmonary disease. Here, we generated an IL-17 KO murine model of hMPV infection and used it to characterize the role of IL-17 hMPV-induced pulmonary inflammation. The results demonstrated that the defect in IL-17 resulted in less neutrophil influx into the lungs, along with reduced ventilatory function. Meanwhile, viral infection in IL-17 KO mice increased regulatory T cells (Tregs) and reduced Th1 and Th2 cells in the lung, suggesting that lack of IL-17 skews the immune response in the lung toward an anti-inflammatory profile, as exhibited by a greater number of Treg cells and fewer Th1 and Th2 cells.


Journal Details

This article was published in the following journal.

Name: Cellular immunology
ISSN: 1090-2163


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