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Magnesium and calcium reduce severity of spatial memory impairments in kainate mouse model of mesial temporal lobe epilepsy.

08:00 EDT 8th August 2018 | BioPortfolio

Summary of "Magnesium and calcium reduce severity of spatial memory impairments in kainate mouse model of mesial temporal lobe epilepsy."

Calcium and magnesium are divalent multipotent ions playing a major role in metabolism, excitability and neuroglial plasticity. Because of these multiple properties, their deficits induce complex brain processes leading to acute or even lasting disorders in excitability and neural networks. These ions are usually prescribed in clinical contexts of neuronal hyperexcitability such as preeclampsia and chronic stress. Our aim was to evaluate whether magnesium at 20 mg / kg and calcium at 100 mg / kg could improve the memory prognosis in the kainic model of mesial temporal epilepsy in mice. The animals were organized into six groups: control group (no kainate), untreated reference group (GR), groups treated from the third day (G1m, G1c), treated groups from the third week (G2m, G2c). The treated mice performed better than GR mice, but magnesium was more effective. The memory (short term / long term) was differently affected by kainate or improved by magnesium / calcium. In addition, magnesium demonstrated an increasing therapeutic effect over time while calcium had an acute and apparently decreasing action in the G1c group that received calcium early.

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This article was published in the following journal.

Name: Canadian journal of physiology and pharmacology
ISSN: 1205-7541
Pages:

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