Relevance of polymorphisms to neuroblastoma risk in Chinese children: a four-center case-control study.

08:00 EDT 8th August 2018 | BioPortfolio

Summary of "Relevance of polymorphisms to neuroblastoma risk in Chinese children: a four-center case-control study."

Neuroblastoma is a lethal tumor that commonly occurs in children. Polymorphisms in reportedly influence risk for several types of cancer, though their roles in neuroblastoma remain unclear. Here we endeavored to determine the relevance of gene polymorphisms and neuroblastoma susceptibility in Chinese children genotyping three polymorphisms (rs3810366, rs13181 and rs238406) in 505 cases and 1070 controls and assessing their contributions to neuroblastoma risk. Overall, we detected no significant association between any single genotype and neuroblastoma risk. When risk genotypes were combined, however, we found that patients with 2-3 risk genotypes were more likely to develop neuroblastoma (adjusted odds ratio =1.31; 95% confidence interval =1.06-1.62, =0.013) than those with 0-1 risk genotypes. Stratification analysis of rs3810366 revealed significant relationships between the subgroups age ≤18 months and clinical stage I+II+4s and neuroblastoma risk. Moreover, the presence of 2-3 risk genotypes was significantly associated with increased neuroblastoma risk in the subgroups age ≤18 months, male, tumor originated from others, and clinical stage I+II+4s. Our findings provide novel insight into the genetic underpinnings of neuroblastoma and demonstrate that polymorphisms may have a cumulative effect on neuroblastoma risk.


Journal Details

This article was published in the following journal.

Name: Aging
ISSN: 1945-4589


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