Effects of low and high doses of acetylsalicylic acid on penicillin-induced epileptiform activity.

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Summary of "Effects of low and high doses of acetylsalicylic acid on penicillin-induced epileptiform activity."

The most common headache associated with epilepsy occurs after seizure activity and is called a postictal headache. Therefore, the objective of this study was to investigate the effects of low and high doses acetylsalicylic acid (aspirin) on a penicillin-induced experimental epilepsy model.


Journal Details

This article was published in the following journal.

Name: Pharmacological reports : PR
ISSN: 1734-1140
Pages: 885-889


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Medical and Biotech [MESH] Definitions

Biphasic dose responses of cells or organisms (including microorganisms) to an exogenous or intrinsic factor, in which the factor induces stimulatory or beneficial effects at low doses and inhibitory or adverse effects at high doses.

An enzyme catalyzing the hydrolysis of penicillin to penicin and a carboxylic acid anion. EC

A muscarinic antagonist used as an antispasmodic, in rhinitis, in urinary incontinence, and in the treatment of ulcers. At high doses it has nicotinic effects resulting in neuromuscular blocking.

Abnormally high temperature intentionally induced in living things regionally or whole body. It is most often induced by radiation (heat waves, infra-red), ultrasound, or drugs.

A penicillin derivative commonly used in the form of its sodium or potassium salts in the treatment of a variety of infections. It is effective against most gram-positive bacteria and against gram-negative cocci. It has also been used as an experimental convulsant because of its actions on GAMMA-AMINOBUTYRIC ACID mediated synaptic transmission.

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