Advertisement

Topics

Tug-of-War in a Dynamic Helical Peptide: Solvent-Induced Helix-Helix Transition of a Lactam-Bridged Peptide Composed of Point- and Axial Chiralities Remote from Each Other.

08:00 EDT 9th August 2018 | BioPortfolio

Summary of "Tug-of-War in a Dynamic Helical Peptide: Solvent-Induced Helix-Helix Transition of a Lactam-Bridged Peptide Composed of Point- and Axial Chiralities Remote from Each Other."

The dynamic axial chirality of oligopeptide-bound 2,2'-bipyridine (bpy) residues can be remote-controlled and diastereoselectively locked. A right-handed (P)-310-helix is first induced in the dynamic helical oligopeptide by an L-valine (L-Val) far from the bpy moiety and the induced axial bpy chirality is diastereoselectively dioxidized. The resulting L-Val-containing linear oligopeptides at the 3,3'-positions retain their (P)-310-helices independent of the axial chirality (aR or aS) of the N-terminal N,N'-dioxide-bpy unit, while a lactam-bridged dynamic helical oligopeptide exhibits a unique solvent-induced helix-helix transition as a result of competitive helix-inducing biases between the L-Val and (aR) or (aS)-N,N'-dioxide-bpy residues remote from each other along the entire oligopeptide chain in a tug-of-war like manner.

Affiliation

Journal Details

This article was published in the following journal.

Name: Chemistry, an Asian journal
ISSN: 1861-471X
Pages:

Links

DeepDyve research library

PubMed Articles [18507 Associated PubMed Articles listed on BioPortfolio]

Helix-loop-helix peptide foldamers and their use in the construction of hydrolase mimetics.

De novo designed helix-loop-helix peptide foldamers containing cis-2-aminocyclopentanecarboxylic acid residues were evaluated for their conformational stability and possible use in enzyme mimetic deve...

Exposing the Nucleation Site in α-Helix Folding: A Joint Experimental and Simulation Study.

One of the fundamental events in protein folding is α-helix formation, which involves sequential development of a series of helical hydrogen-bonds between the backbone C=O group of residues i and the...

Post-assembly α-helix to β-sheet structural transformation within SAF-p1/p2a peptide nanofibers.

We report an unanticipated helix-to-sheet structural transformation within an assembly of SAF-p1 and SAF-p2a designer peptides. Solid-state NMR spectroscopic data support the assembled structure that ...

Deprotonation of a Single Amino Acid Residue Induces Significant Stability in an α-Helical Heteropeptide.

Stability of secondary structural elements is an integral component of a structurally stable protein. Presence of protons in the residue sequence and their immediate environment play a significant rol...

Dynamic ion pair behavior stabilizes single alpha helices in proteins.

Ion pairs are key stabilizing interactions between oppositely charged amino acid side chains in proteins. They are often depicted as single conformer salt bridges (hydrogen-bonded ion pairs) in crysta...

Clinical Trials [4568 Associated Clinical Trials listed on BioPortfolio]

Neodent Implantable Devices of GM Line

Acqua GM (Grand Morse) Helix implants present an optimized implant design with adapted treatment protocol, allowing for treatment of patients with different bone qualities. The objective ...

Clinical Trial Phase I-II of Efficacy and Safety of Snail Slime and Natural Extracts for Healing in Diabetic Foot Ulcers

The primary objective is to evaluate the efficacy and safety of the use of a formulation of snail slime and natural extracts, for the curative treatment of ulcer wonds in diabetic foot. ...

The Effect of Solvent Usage on Post-treatment Pain

No clinical evidence has been yet published regarding the comparison of postoperative pain after removal of the root canal fillings with or without solvent. The aim of this study was to ev...

HELIX, a Double-masked Study of SYL1001 in Patients With Moderate to Severe Dry Eye Disease (DED)

The purpose of this study is to determine whether SYL1001 ophthalmic solution is safe and effective in the treatment of signs and symptoms of Dry Eye Disease.

Helical Tomotherapy as a Radiotherapy Technique for Treating Bone Metastases

To assess the safety and efficacy of a single fraction of radiotherapy using helical tomotherapy to treat bone metastases.

Medical and Biotech [MESH] Definitions

Recurring supersecondary structures characterized by 20 amino acids folding into two alpha helices connected by a non-helical "loop" segment. They are found in many sequence-specific DNA-BINDING PROTEINS and in CALCIUM-BINDING PROTEINS.

A highly-conserved family of basic helix-loop-helix (bHLH) transcription factors. They function as dimers with other bHLH proteins and bind E-BOX ELEMENTS to control gene expression during EMBRYOGENESIS and the EPITHELIAL-MESENCHYMAL TRANSITION.

A subfamily of HELIX-TURN-HELIX DNA-binding proteins that contain a variable length loop adjacent to the HTH motif. The loop connects two anti-parallel strands and forms a wing when bound to DNA.

A family of DNA-binding transcription factors that contain a basic HELIX-LOOP-HELIX MOTIF.

A family of transcription factors that contain regions rich in basic residues, LEUCINE ZIPPER domains, and HELIX-LOOP-HELIX MOTIFS.

Advertisement
Quick Search
Advertisement
Advertisement

 


DeepDyve research library

Searches Linking to this Article