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Biogenic carbonyls, especially aldehydes, have previously demonstrated the potential to serve as early diagnostic biomarkers for disease and injury, which have not been fully realized due in part to the lack of a rapid and simple point-of-care method of aldehyde identification. The ability to determine which carbonyl compound is elevated, and not just total aldehydic load, may provide more disease- or injury-specific diagnostic information. Toward this end, a novel fluorophore is presented, capable of catalyst-free complexation of biogenic carbonyls that results in a fluorescent fingerprint of the resulting hydrazone. The successful identification of bound carbonyls was accomplished with a newly described algorithm that applies principal curvature analysis of excitation-emission matrices to reduce surface features to ellipse representations, followed by a pattern matching routine. With this algorithm, carbonyls were identified over a range of concentrations, and mixture components were successfully parsed. Overall, the results presented lay the groundwork for novel implementations of chemometrics to low cost, rapid, and simply-implemented point-of-care diagnostics.
This article was published in the following journal.
Name: Chembiochem : a European journal of chemical biology
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The analysis of a critical number of sensory stimuli or facts (the pattern) by physiological processes such as vision (PATTERN RECOGNITION, VISUAL), touch, or hearing.
Mental process to visually perceive a critical number of facts (the pattern), such as characters, shapes, displays, or designs.
Pathogens' molecules with specific sequence patterns that are recognized by PATTERN RECOGNITION RECEPTORS. They include microbial DNA, double-stranded RNA, surface glycoproteins, lipopolysaccharides, peptidoglycans, and lipoteichoic acid.
Cell surface proteins that bind biogenic amines with high affinity and regulate intracellular signals which influence the behavior of cells. Biogenic amine is a chemically imprecise term which, by convention, includes the catecholamines epinephrine, norepinephrine, and dopamine, the indoleamine serotonin, the imidazolamine histamine, and compounds closely related to each of these.
A family of pattern recognition receptors characterized by an extracellular leucine-rich domain and a cytoplasmic domain that share homology with the INTERLEUKIN 1 RECEPTOR and the DROSOPHILA toll protein. Following pathogen recognition, toll-like receptors recruit and activate a variety of SIGNAL TRANSDUCING ADAPTOR PROTEINS.