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Comparison of ischemia/reperfusion-induced acute kidney injury by clamping renal arteries, veins, or pedicles in anaesthetised rats.

08:00 EDT 9th August 2018 | BioPortfolio

Summary of "Comparison of ischemia/reperfusion-induced acute kidney injury by clamping renal arteries, veins, or pedicles in anaesthetised rats."

What is central question of this study? Acute kidney injury (AKI) in patients is usually due to renal artery hypoperfusion or occasionally vein thrombosis, but murine model of ischemic AKI is mostly induced via pedicle-clamping. Hence, the traditional renal pedicle-clamping model was compared with models of occluding renal artery or vein alone in rats. What is main finding and its importance? During renal venous occlusion, transmission of high arterial pressure into renal capillaries likely caused rupture of their walls and occurrence of hemorrhagic congestion that led to higher kidney tissue damage and dysfunction than pedicle and artery clamping.

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This article was published in the following journal.

Name: Experimental physiology
ISSN: 1469-445X
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Medical and Biotech [MESH] Definitions

Generally, restoration of blood supply to heart tissue which is ischemic due to decrease in normal blood supply. The decrease may result from any source including atherosclerotic obstruction, narrowing of the artery, or surgical clamping. Reperfusion can be induced to treat ischemia. Methods include chemical dissolution of an occluding thrombus, administration of vasodilator drugs, angioplasty, catheterization, and artery bypass graft surgery. However, it is thought that reperfusion can itself further damage the ischemic tissue, causing MYOCARDIAL REPERFUSION INJURY.

Restoration of blood supply to tissue which is ischemic due to decrease in normal blood supply. The decrease may result from any source including atherosclerotic obstruction, narrowing of the artery, or surgical clamping. It is primarily a procedure for treating infarction or other ischemia, by enabling viable ischemic tissue to recover, thus limiting further necrosis. However, it is thought that reperfusion can itself further damage the ischemic tissue, causing REPERFUSION INJURY.

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Adverse functional, metabolic, or structural changes in ischemic tissues resulting from the restoration of blood flow to the tissue (REPERFUSION), including swelling; HEMORRHAGE; NECROSIS; and damage from FREE RADICALS. The most common instance is MYOCARDIAL REPERFUSION INJURY.

A form of ischemia-reperfusion injury occurring in the early period following transplantation. Significant pathophysiological changes in MITOCHONDRIA are the main cause of the dysfunction. It is most often seen in the transplanted lung, liver, or kidney and can lead to GRAFT REJECTION.

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