The effects of emamectin benzoate or ivermectin spiked sediment on juvenile American lobsters (Homarus americanus).

08:00 EDT 7th August 2018 | BioPortfolio

Summary of "The effects of emamectin benzoate or ivermectin spiked sediment on juvenile American lobsters (Homarus americanus)."

This study examined the effects of a range of ½-log concentrations of emamectin benzoate (commercially applied as SLICE) and ivermectin (commercially applied as IVOMEC) on juvenile American lobster, Homarus americanus. Phase I of the research assessed acute (up to 4 days) and chronic (30-day) toxicity of sediment dosed with the active ingredients emamectin benzoate (EMB) formulated as SLICE or ivermectin (IVM) formulated as IVOMEC at various nominal concentrations (
15, 48, 150, 475 and 1500 ng g wet sediment;
3, 9.5, 30, 95 and 300 ng g wet sediment) on juvenile Atlantic lobster (stages IV). Phase II evaluated sublethal effects (e.g., growth, moulting success) of all lobster surviving past the 30 day exposure period, over an additional 41 days. Chemical analysis of EMB and IVM in sediment samples from the exposure tanks revealed a strong linear association (R values 0.99 and 0.98 for EMB and IVM, respectively) between nominal dose and measured concentration of compound. EMB exposure concentrations at very high levels (≥ 343.3 ng g) were acutely toxic to juvenile lobster such that 100% of lobsters had died after 13 days of exposure. The maximum cumulative mortality of lobsters exposed to the highest concentrations of EMB and IVM was 100% after 10 days and 25 days, respectively. The 10-day LC estimates (± 95% CI) for EMB and IVM were 250.23 ± 90.4 and 212.14 ± 202.64 ng g, respectively. Using abnormal behaviour as an indicator, the 15-day EC estimates (± 95% CI) for EMB and IVM were 96.19 ± 51.42 and 15.82 ± 6.93 ng g, respectively. The NOEC (no observed effect concentration) for abnormal behaviour was 0.0 ng g for each product and the LOEC (lowest observed effect concentration) was 8.8 and > 3.0 ng g for EMB and IVM, respectively. Observations on sublethal effects included delayed moulting to stage VI and reduced growth at higher exposure concentrations for both therapeutants. Using failure to moult to stage V or VI as an indicator, the 15-day EC estimates (± 95% CI) for EMB and IVM were 32.72 ± 18.26 and 14.00 ± 12.43 ng g, respectively. The NOEC for failure to moult to stage V only was 343.3 and 14.7 ng g for EMB and IVM, respectively. Whereas, the LOEC was 1066.7 and > 61.0 ng g for EMB and IVM, respectively. The concentrations of EMB and IVM tested in the present study were acutely toxic to juvenile lobster exposed to the highest dosages (343.3 and 1066.7 ng EMB g and 61.0 and 300.0 ng IVM g). There was significant evidence of chronic toxicity, longer exposure increased mortality with LT values decreasing with increasing test material concentration.


Journal Details

This article was published in the following journal.

Name: Ecotoxicology and environmental safety
ISSN: 1090-2414
Pages: 636-645


DeepDyve research library

PubMed Articles [22280 Associated PubMed Articles listed on BioPortfolio]

Lethal and sublethal effects of emamectin benzoate on the rove beetle, Paederus fuscipes, a non-target predator of rice brown planthopper, Nilaparvata lugens.

The use of pesticides in rice can not only manage the pest but also influence non-target organisms. The rove beetle (Paederus fuscipes), which is an important predator of the brown plant hopper (Nilap...

Comparative effects of the parasiticide ivermectin on survival and reproduction of adult sepsid flies.

Ivermectin is a veterinary pharmaceutical widely applied against parasites of livestock. Being effective against pests, it is also known to have lethal and sublethal effects on non-target organisms. W...

The effect of α-tocopherol and dithiothreitol in ameliorating emamectin benzoate cytotoxicity in human K562 cells involving the modulation of ROS accumulation and NF-κB signaling.

Emamectin benzoate (EMB) toxicity contributes a potential risk to environment and human health. To investigate the effect of α-tocopherol (VitE) and dithiothreitol (DTT) in ameliorating EMB-induced c...

Activity of acetylcholinesterase and acid and alkaline phosphatases in different insecticide-treated Helicoverpa armigera (Hübner).

Helicoverpa armigera is a major devastating insect pest on a wide range of vegetables and cash crops. Insecticides are presently indispensable for its control in nearly all crops. H. armigera has acqu...

Pharmacokinetics-Pharmacodynamics of High-Dose Ivermectin with Dihydroartemisinin-Piperaquine on Mosquitocidal Activity and QT-prolongation (IVERMAL).

High-dose ivermectin, co-administered for 3-days with dihydroartemisinin-piperaquine (DP), killed mosquitoes feeding on individuals for at least 28-days post-treatment in a recent trial (IVERMAL), whi...

Clinical Trials [2300 Associated Clinical Trials listed on BioPortfolio]

Ocular Changes After Ivermectin - (DOLF IVM/Oncho)

The DOLF Ocular Changes after Ivermectin study will investigate the kinetics of O. volvulus microfilaria (Mf) in the eye following treatment with ivermectin. The primary objective is to de...

Comparative Efficacy of Phenylbutyrate (PBA) vs. Benzoate in Urea Cycle Disorders

The investigators will study and compare how effectively sodium phenylbutyrate, sodium benzoate, and a combination of the two, help excrete nitrogen in healthy volunteers. Subject particip...

A Bioequivalence Study, Comparing Two Formulations of Ivermectin Lotion, 0.5%

A Multi-Center, Double-Blind, Randomized, Placebo controlled, Parallel-group study, comparing Ivermectin Lotion, 0.5%

Bioavailability Pilot Study of Versus W0035 Versus Stromectol

Ivermectin is prescribed for the treatment of helminthic infections sensitive to ivermectin. However, it is currently only available as a tablet formulation. W0035 is a powder for oral sus...

Sodium Benzoate and/or N-Acetylcysteine Added to TAU in Patients With Early Schizophrenia Spectrum Disorder.

This study aims to determine if the addition of Sodium Benzoate and / or NAC to TAU will be acceptable and tolerable and result in overall improvement of symptoms, social and cognitive fun...

Medical and Biotech [MESH] Definitions

An enzyme that catalyzes the oxidation of BENZOATE to 4-hydroxybenzoate. It requires IRON and tetrahydropteridine.

Arthritis in children, with onset before 16 years of age. The terms juvenile rheumatoid arthritis (JRA) and juvenile idiopathic arthritis (JIA) refer to classification systems for chronic arthritis in children. Only one subtype of juvenile arthritis (polyarticular-onset, rheumatoid factor-positive) clinically resembles adult rheumatoid arthritis and is considered its childhood equivalent.

Alkaloids with powerful hypotensive effects isolated from American or European Hellebore (Veratrum viride Ait. Liliaceae and Veratrum album L. Liliaceae). They increase cholinergic and decrease adrenergic tone with appropriate side effects and at higher doses depress respiration and produce cardiac arrhythmias; only the ester alkaloids have been used as hypotensive agents in specific instances. They have been generally replaced by drugs with fewer adverse effects.

Rheumatoid arthritis of children occurring in three major subtypes defined by the symptoms present during the first six months following onset: systemic-onset (Still's Disease, Juvenile-Onset), polyarticular-onset, and pauciarticular-onset. Adult-onset cases of Still's disease (STILL'S DISEASE, ADULT-ONSET) are also known. Only one subtype of juvenile rheumatoid arthritis (polyarticular-onset, rheumatoid factor-positive) clinically resembles adult rheumatoid arthritis and is considered its childhood equivalent.

Armed conflict that resulted in separation of American colonies from Britain and established the United States of America.

Quick Search


DeepDyve research library

Relevant Topic

Clincial Trials
In a clinical trial or interventional study, participants receive specific interventions according to the research plan or protocol created by the investigators. These interventions may be medical products, such as drugs or devices; procedures; or change...

Searches Linking to this Article