Mechanical characterisation of brain tissue up to 35% strain at 1, 10, and 100/s using a custom-built micro-indentation apparatus.

08:00 EDT 17th July 2018 | BioPortfolio

Summary of "Mechanical characterisation of brain tissue up to 35% strain at 1, 10, and 100/s using a custom-built micro-indentation apparatus."

Understanding the behaviour of soft tissues under large strains and high loading rates is crucial in the field of biomechanics in order to investigate tissue behaviour during pathological processes such as traumatic brain injury (TBI). It is, therefore, necessary to characterise the mechanical properties of such tissues under large strain and high strain rates that are similar to those experienced during injury. However, there is a dearth of large strain and high rate mechanical properties for brain tissue. This is likely driven by the lack of commercially available equipment to perform such tests and the difficulties associated with developing appropriate custom-built apparatus. Here, we address this problem by presenting a novel, custom-built micro-indentation apparatus that is capable of characterising the mechanical properties of brain tissue up to 35% at 100/s with a spatial resolution of 250 µm. Indentations were performed on the cortex and cerebellum of five-week-old mouse brains up to 35% strain at 1, 10, and 100/s. Three hyperelastic models were fitted to the experimental data that demonstrate the strong rate-dependency of the tissue. The neo-Hookean shear modulus for the cortex tissue was calculated to be 2.36 ± 0.46, 3.64 ± 0.48, and 8.98 ± 0.66 kPa (mean ± SD) for 1, 10, and 100/s, respectively. Similarly, the cerebellum shear modulus was calculated to be 1.12 ± 0.26, 1.58 ± 0.32, 3.10 ± 0.70 kPa for 1, 10, and 100/s, respectively. Student's t-tests were used to show statistically significant differences between the cortex and cerebellum at each strain rate. Furthermore, we discuss the apparent strain-softening effect in the 100/s force-displacement curves for both regions after approximately 30% strain.


Journal Details

This article was published in the following journal.

Name: Journal of the mechanical behavior of biomedical materials
ISSN: 1878-0180
Pages: 256-266


DeepDyve research library

PubMed Articles [18280 Associated PubMed Articles listed on BioPortfolio]

Application of the time-strain superposition - Part II: Prediction of the frequency-dependent behaviour of brain tissue.

Knowing the real material properties of brain tissue is of great importance when it comes to the precise prediction of its mechanical response. The efficiency of these procedures depends on the adequa...

Compressive properties and constitutive modeling of different regions of 8-week-old pediatric porcine brain under large strain and wide strain rates.

Porcine head is often used as a human surrogate in traumatic head injury research. Extensive research on mechanical properties of adult human/porcine brain tissues has been performed previously; howev...

Intraoperative Strain Elastosonography in Brain Tumor Surgery.

Sonoelastography is an ultrasound imaging technique able to assess mechanical properties of tissues. Strain elastography (SE) is a qualitative sonoelastographic modality with a wide range of clinical ...

Effect of SR-microCT radiation on the mechanical integrity of trabecular bone using in situ mechanical testing and digital volume correlation.

The use of synchrotron radiation micro-computed tomography (SR-microCT) is becoming increasingly popular for studying the relationship between microstructure and bone mechanics subjected to in situ me...

Regional mechanical and biochemical properties of the porcine cortical meninges.

The meninges are pivotal in protecting the brain against traumatic brain injury (TBI), an ongoing issue in most mainstream sports. Improved understanding of TBI biomechanics and pathophysiology is des...

Clinical Trials [8631 Associated Clinical Trials listed on BioPortfolio]

Influence of Mechanical Stimulus on Distraction Osteogenesis

a further step of our current one-year NSC project, aiming to bridge the above-mentioned gap by continuously monitoring the mechanical stimuli applied to the limb and callus, both through ...

Studying Movement Control in PD Using Closed Loop DBS

Parkinson's disease (PD) is a common, disabling, progressive condition characterised by severe problems with movement for which medical treatment in the longer term can be unsatisfactory. ...

A New Ultrasonographic Tool to Assess Pulmonary Strain in the ICU

The primary objective of the study is to create a small dataset of regional pulmonary strain values in patients suffering from pulmonary diseases under mechanical ventilation in an intensi...

Chairside Time and Bond Failure of Non Custom Versus Custom Base Orthodontic Attachments During Indirect Bonding

compare the chair side time, clinical orthodontic attachment bond failure and accuracy of transfer between non custom attachment base and custom attachment base indirect techniques.

STACCATO: Stent sTrut Apposition and Coverage in Coronary ArTeries: an Optical Coherence Tomography (OCT) Study

Assessment of vessel healing after DES implantation in STEMI, NSTEMI and stable/unstable angina patients: a randomized comparison between everolimus and biolimus A9-eluting stents: an opti...

Medical and Biotech [MESH] Definitions

Tissue NECROSIS in any area of the brain, including the CEREBRAL HEMISPHERES, the CEREBELLUM, and the BRAIN STEM. Brain infarction is the result of a cascade of events initiated by inadequate blood flow through the brain that is followed by HYPOXIA and HYPOGLYCEMIA in brain tissue. Damage may be temporary, permanent, selective or pan-necrosis.

Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.

A purely physical condition which exists within any material because of strain or deformation by external forces or by non-uniform thermal expansion; expressed quantitatively in units of force per unit area.

Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.

Transference of brain tissue, either from a fetus or from a born individual, between individuals of the same species or between individuals of different species.

Quick Search


DeepDyve research library

Relevant Topic

Anxiety Disorders
Anxiety is caused by stress. It is a natural reaction, and is beneficial in helping us deal with tense situations and pressure. It is deterimental when is becomes an excessive, irrational dread of everyday situations. The most common types of anxiety di...

Searches Linking to this Article