Track topics on Twitter Track topics that are important to you
Understanding the behaviour of soft tissues under large strains and high loading rates is crucial in the field of biomechanics in order to investigate tissue behaviour during pathological processes such as traumatic brain injury (TBI). It is, therefore, necessary to characterise the mechanical properties of such tissues under large strain and high strain rates that are similar to those experienced during injury. However, there is a dearth of large strain and high rate mechanical properties for brain tissue. This is likely driven by the lack of commercially available equipment to perform such tests and the difficulties associated with developing appropriate custom-built apparatus. Here, we address this problem by presenting a novel, custom-built micro-indentation apparatus that is capable of characterising the mechanical properties of brain tissue up to 35% at 100/s with a spatial resolution of 250 µm. Indentations were performed on the cortex and cerebellum of five-week-old mouse brains up to 35% strain at 1, 10, and 100/s. Three hyperelastic models were fitted to the experimental data that demonstrate the strong rate-dependency of the tissue. The neo-Hookean shear modulus for the cortex tissue was calculated to be 2.36 ± 0.46, 3.64 ± 0.48, and 8.98 ± 0.66 kPa (mean ± SD) for 1, 10, and 100/s, respectively. Similarly, the cerebellum shear modulus was calculated to be 1.12 ± 0.26, 1.58 ± 0.32, 3.10 ± 0.70 kPa for 1, 10, and 100/s, respectively. Student's t-tests were used to show statistically significant differences between the cortex and cerebellum at each strain rate. Furthermore, we discuss the apparent strain-softening effect in the 100/s force-displacement curves for both regions after approximately 30% strain.
This article was published in the following journal.
Name: Journal of the mechanical behavior of biomedical materials
Knowledge of brain tissue mechanical properties may be critical for formulating hypotheses about some specific diseases mechanisms and its accurate simulations such as traumatic brain injury (TBI) and...
Accurate characterization of the mechanical properties of brain tissue is essential for understanding the mechanisms of traumatic brain injuries and developing protective gears or facilities. However,...
Being extremely soft, brain tissue is among the most challenging materials to be mechanically quantified. Despite recent advances in mechanical testing of ultra-soft matters, there still exists a need...
Knowing the real material properties of brain tissue is of great importance when it comes to the precise prediction of its mechanical response. The efficiency of these procedures depends on the adequa...
An electromagnetic actuator was designed for magnetic resonance elastography (MRE). The actuator is unique in that it is simple, portable, and capable of brain, abdomen, and phantom imagings. A custom...
a further step of our current one-year NSC project, aiming to bridge the above-mentioned gap by continuously monitoring the mechanical stimuli applied to the limb and callus, both through ...
Parkinson's disease (PD) is a common, disabling, progressive condition characterised by severe problems with movement for which medical treatment in the longer term can be unsatisfactory. ...
The primary objective of the study is to create a small dataset of regional pulmonary strain values in patients suffering from pulmonary diseases under mechanical ventilation in an intensi...
compare the chair side time, clinical orthodontic attachment bond failure and accuracy of transfer between non custom attachment base and custom attachment base indirect techniques.
Assessment of vessel healing after DES implantation in STEMI, NSTEMI and stable/unstable angina patients: a randomized comparison between everolimus and biolimus A9-eluting stents: an opti...
Tissue NECROSIS in any area of the brain, including the CEREBRAL HEMISPHERES, the CEREBELLUM, and the BRAIN STEM. Brain infarction is the result of a cascade of events initiated by inadequate blood flow through the brain that is followed by HYPOXIA and HYPOGLYCEMIA in brain tissue. Damage may be temporary, permanent, selective or pan-necrosis.
Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.
A purely physical condition which exists within any material because of strain or deformation by external forces or by non-uniform thermal expansion; expressed quantitatively in units of force per unit area.
Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.
Transference of brain tissue, either from a fetus or from a born individual, between individuals of the same species or between individuals of different species.
Anxiety is caused by stress. It is a natural reaction, and is beneficial in helping us deal with tense situations and pressure. It is deterimental when is becomes an excessive, irrational dread of everyday situations. The most common types of anxiety di...