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Ipilimumab for the treatment of advanced melanoma in six kidney transplant patients.

08:00 EDT 14th August 2018 | BioPortfolio

Summary of "Ipilimumab for the treatment of advanced melanoma in six kidney transplant patients."

Immune checkpoint inhibitors are new therapeutic options for metastatic melanoma, but little data is available in organ transplant recipient populations. Six French patients, 3 men and 3 women, mean age 66 years (range 44-74), all kidney transplant recipients, received ipilimumab (CTLA-4 inhibitor) for metastatic melanoma. At diagnosis of advanced melanoma, immunosuppressive therapy had been minimized in all but one. Adverse effects included one case of grade 1 diarrhea and one grade 1 pruritus. One patient had acute T-cell-mediated rejection confirmed by histology, after the first injection of ipilimumab. After a median follow-up of 4.5 (3-20) months, one patient achieved partial response, one had stable disease and four had disease progression. All the patients died, 5 from melanoma, 1 from another cause. In this series and in the literature, ipilimumab proves to be safe and possibly active. The acute rejection we encountered was probably related to both a rapid, drastic reduction of immunosuppression and to the use of ipilimumab. Our safety data on ipilimumab contrasts with the organ transplant rejections already reported with PD-1 inhibitors. We consider that immunosuppression should not be minimized, as the impact on metastatic disease control is probably small. This article is protected by copyright. All rights reserved.

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This article was published in the following journal.

Name: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
ISSN: 1600-6143
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